7-hydroxy-4,6-dimethy-3H-isobenzofuran-1-one | 10088-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 7-hydroxy-4,6-dimethy-3H-isobenzofuran-1-one
• 英文别名: 7-hydroxy-4,6-dimethylphtalide；7-hydroxy-4,6-dimethyl-3H-isobenzofuran-1-one；7-hydroxy-4,6-dimethyl-phthalide；7-Hydroxy-4,6-dimethyl-phthalid；7-Hydroxy-4.6-dimethyl-phthalid；1(3H)-Isobenzofuranone, 7-hydroxy-4,6-dimethyl-；7-hydroxy-4,6-dimethyl-3H-2-benzofuran-1-one
• CAS: 10088-77-4
• 化学式: C₁₀H₁₀O₃
• 分子量: 178.188
• InChiKey: FCSPXCQJNMMNMO-UHFFFAOYSA-N

物化性质

• 熔点：
  159.5-160.5 °C
• 沸点：
  428.7±45.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one 在 氢溴酸 作用下， 生成 7-hydroxy-4,6-dimethy-3H-isobenzofuran-1-one
  参考文献：
  名称：

  Grove, Biochemical Journal, 1952, vol. 50, p. 648,661

  摘要：

  DOI：

文献信息

• EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME
  申请人：HAYASHIBARA CO., LTD.

  公开号：US20150342854A1

  公开（公告）日：2015-12-03

  The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

  本发明的目的是提供一种用于抗衰老的外用皮肤组成物，该组成物可以预防或改善因年龄增长或衰老引起的皮肤问题，如皱纹、细纹、斑点和下垂，并维持或改善皮肤的屏障功能和透明质酸的产生。本发明通过提供一种外用皮肤组成物来实现该目的，该组成物包含水性介质作为基材料，并含有一种或多种从L-抗坏血酸、其衍生物和它们的盐中选择的成分作为有效成分。
• EXTERNAL PREPARATION FOR SKIN FOR REDUCING SKIN YELLOWNESS
  申请人：Hayashibara Co., Ltd.

  公开号：EP3342396A1

  公开（公告）日：2018-07-04

  [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin. [Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).

  [目的]本发明的目的是提供一种用于减轻皮肤中已产生的皮肤黄染的外用皮肤剂。 [达到目的的方法】本发明的上述目的是通过提供一种用于减轻皮肤已有黄染现象的外用皮肤剂来实现的，该外用皮肤剂含有橙皮素和/或糖基橙皮素作为有效成分。
• External dermal composition for anti-ageing and method for producing the same
  申请人：Hayashibara Co., Ltd.

  公开号：US10111822B2

  公开（公告）日：2018-10-30

  The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

  本发明的目的是提供一种用于抗衰老的外用真皮组合物，该组合物可预防或改善因年龄增长或老化引起的皱纹、细小皱纹、斑点和疤痕等明显的皮肤问题，并保持或改善皮肤的屏障功能和透明质酸的生成。本发明的目的是提供一种用于抗衰老的外用皮肤组合物，该组合物含有作为基质材料的水介质和作为有效成分的一种或多种选自 L-抗坏血酸、其衍生物及其盐类的成分。
• External dermal agent for reducing yellowish dullness
  申请人：Hayashibara Co., Ltd.

  公开号：US10568827B2

  公开（公告）日：2020-02-25

  [Object] The present invention has an object to provide an external dermal agent for reducing skin yellowness already generated in the skin. [Means to Attain the Object] The above object is solved by providing an external dermal agent for reducing skin yellowness already generated in the skin, which contains hesperetin and/or glycosyl hesperetin as an effective ingredient(s).

  [目的]本发明的目的是提供一种用于减轻皮肤中已产生的皮肤黄染的外用皮肤剂。 [达到目的的方法】本发明的上述目的是通过提供一种用于减轻皮肤已有黄染现象的外用皮肤剂来实现的，该外用皮肤剂含有橙皮素和/或糖基橙皮素作为有效成分。
• Raistrick; Ross, Biochemical Journal, 1952, vol. 50, p. 635,645
  作者：Raistrick、Ross

  DOI：——

  日期：——