tetrakis(4-isocyanatophenyl)methane | 697746-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tetrakis(4-isocyanatophenyl)methane
• 英文别名: 1-isocyanato-4-[tris(4-isocyanatophenyl)methyl]benzene
• CAS: 697746-87-5
• 化学式: C₂₉H₁₆N₄O₄
• 分子量: 484.47
• InChiKey: SBPHDJANZYGCGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  596.8±50.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  tetrakis(4-isocyanatophenyl)methane 在 ammonium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以92%的产率得到N,N',N'',N'''-(methylenetetrayltetra-4,1-phenylene)tetrakis-urea
  参考文献：
  名称：

  分子构造？？使用衍生自四苯基甲烷和四苯基硅烷的氨基甲酸酯和脲来构建多孔手性氢键网络

  摘要：

  四苯基甲烷、四苯基硅烷和带有不参与氢键的取代基的简单衍生物通常结晶为密堆积结构，基本上没有空间可容纳客体。相比之下，已知具有氢键基团的衍生物有利于形成包含大量客体的开放网络。为了探究这一现象，我们合成了六种新的四苯基甲烷和四苯基硅烷衍生物5a??5e 和6a，在对位具有氨基甲酸乙酯和脲基团，对化合物进行结晶，并通过X 射线晶体学确定它们的结构。正如预期的那样，所有六种化合物都结晶形成多孔的三维氢键网络。在四脲 5e 的情况下，66% 的晶体体积可供客人使用，客体可以交换成单晶而不会损失结晶度。特别值得注意的是：（i）使用四（4-异氰酸根合苯基）甲烷（1f）作为制备对映体的前体......

  DOI：

  10.1139/v03-208
• 作为产物：
  描述：

  1-硝基-4-[三(4-硝基苯基)甲基]苯 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， -78.0~25.0 ℃ 、1.2 MPa 条件下， 反应 72.0h， 生成 tetrakis(4-isocyanatophenyl)methane
  参考文献：
  名称：

  分子构造？？使用衍生自四苯基甲烷和四苯基硅烷的氨基甲酸酯和脲来构建多孔手性氢键网络

  摘要：

  四苯基甲烷、四苯基硅烷和带有不参与氢键的取代基的简单衍生物通常结晶为密堆积结构，基本上没有空间可容纳客体。相比之下，已知具有氢键基团的衍生物有利于形成包含大量客体的开放网络。为了探究这一现象，我们合成了六种新的四苯基甲烷和四苯基硅烷衍生物5a??5e 和6a，在对位具有氨基甲酸乙酯和脲基团，对化合物进行结晶，并通过X 射线晶体学确定它们的结构。正如预期的那样，所有六种化合物都结晶形成多孔的三维氢键网络。在四脲 5e 的情况下，66% 的晶体体积可供客人使用，客体可以交换成单晶而不会损失结晶度。特别值得注意的是：（i）使用四（4-异氰酸根合苯基）甲烷（1f）作为制备对映体的前体......

  DOI：

  10.1139/v03-208

文献信息

• Porous membrane having immobilized enzyme, porous membrane composite including the same, and preparation method thereof
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US10202596B2

  公开（公告）日：2019-02-12

  Disclosed herein is a porous membrane having an immobilized enzyme wherein the enzyme is immobilized within pores which are three-dimensionally connected to each other. The porous membrane having the immobilized enzyme is three-dimensionally crosslinked in a molecular level wherein nanopores of 5 to 100 nm are interconnected, so that the immobilized enzyme may be in contact with a reactant in all directions, and the reaction solution may be easily diffused, thereby proceeding with the catalytic reaction fast and conveniently without deterioration of material transport.

  本文公开了一种具有固定化酶的多孔膜，其中酶被固定在彼此三维连接的孔内。具有固定化酶的多孔膜在分子水平上进行了三维交联，其中 5 至 100 nm 的纳米孔相互连接，从而使固定化酶可以在各个方向上与反应物接触，并且反应溶液可以很容易地扩散，从而快速、方便地进行催化反应，而不会影响材料的运输。
• Enzyme-immobilized porous membrane and preparation method of antibiotics using the same
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US11359224B2

  公开（公告）日：2022-06-14

  The present disclosure relates to an enzyme-immobilized porous membrane and a preparation method of antibiotics using the same, and more specifically, to an enzyme-immobilized porous membrane prepared by immobilizing a specific enzyme through dead-end filtration, and a preparation method of antibiotics with a high yield using the enzyme-immobilized porous membrane. According to various exemplary embodiments of the present disclosure, the enzyme capable of promoting the synthesis reaction of the antibiotic substance is able to be stably immobilized in the porous membrane by passing the solution of enzyme through the membrane. In addition, it is possible to provide antibiotics with a high yield by preparing the antibiotics by passing the reactant solution through the enzyme-immobilized porous membrane.

  本公开涉及一种酶固定化多孔膜和利用其制备抗生素的方法，更具体地说，涉及一种通过死端过滤固定特定酶制备的酶固定化多孔膜，以及利用该酶固定化多孔膜制备高产率抗生素的方法。 根据本公开的各种示例性实施方案，通过将酶溶液穿过多孔膜，能够将能够促进抗生素物质合成反应的酶稳定地固定在多孔膜中。 此外，通过将反应物溶液通过酶固定多孔膜来制备抗生素，可以提供高产率的抗生素。
• POROUS POLYUREA MATERIAL AND METHODS FOR PREPARING THE SAME
  申请人：Park Ji-Woong

  公开号：US20120095123A1

  公开（公告）日：2012-04-19

  The present invention relates to a porous polyurea material and a method for preparing the same. The porous polyurea material may be prepared by polymerization and crosslinking of tetra(4-aminophenyl)methane with a monomer two to four isocyanate (—NCO) groups. The method includes: mixing an organic solution of tetra(4-aminophenyl)methane with an organic solution of a monomer having two to four isocyanate groups; reacting the mixed solution under a nitrogen atmosphere; and drying a semi-solid or solid material formed by gelation of the reaction solution, or adding the reaction solution to a non-solvent before gelation of the reaction solution to form a precipitate, followed by drying, or applying the reaction solution to a substrate before gelation of the reaction solution, followed by drying. According to the present invention, the introduction of the monomer having a tetrahedral structure can impart good chemical resistance, heat resistance and durability to the porous polyurea material.
• 3D COVALENT MOLECULAR NETWORK NANOCAPSULE AND PREPARING METHOD THEREOF
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20140312278A1

  公开（公告）日：2014-10-23

  Disclosed herein are a polymer nanocapsule and a preparing method thereof, and more particularly, a 3D covalent molecular network nanocapsule, and a preparing method thereof. According to the present invention, a nanocapsule having thermal stability and solvent resistance due to a 3D covalent molecular network structure may be easily prepared without performing an additional post-processing process such as addition of a cross-linking agent or catalyst or removal of a template or core. Since the nanocapsule formed as described above may support an organic dye, metal particles, and the like, it is expected that the nanocapsule will be variously applied to material storage and transport, drug delivery, and the like.
• POROUS MEMBRANE HAVING IMMOBILIZED ENZYME, POROUS MEMBRANE COMPOSITE INCLUDING THE SAME, AND PREPARATION METHOD THEREOF
  申请人：GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20150099288A1

  公开（公告）日：2015-04-09

  Disclosed herein is a porous membrane having an immobilized enzyme wherein the enzyme is immobilized within pores which are three-dimensionally connected to each other. The porous membrane having the immobilized enzyme is three-dimensionally crosslinked in a molecular level wherein nanopores of 5 to 100 nm are interconnected, so that the immobilized enzyme may be in contact with a reactant in all directions, and the reaction solution may be easily diffused, thereby proceeding with the catalytic reaction fast and conveniently without deterioration of material transport.