bis(2-acetylaminoethyl) sulfide | 92349-49-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis(2-acetylaminoethyl) sulfide
• 英文别名: bis(2-aminoethyl)sulfide；N,N'-(3-thia-pentanediyl)-bis-acetamide；N,N'-(3-Thia-pentandiyl)-bis-acetamid；Bis-(2-acetylamino-aethyl)-sulfid；(β-Acetamidoethyl)-sulfid；N-{2-[(2-Acetamidoethyl)sulfanyl]ethyl}acetamide；N-[2-(2-acetamidoethylsulfanyl)ethyl]acetamide
• CAS: 92349-49-0
• 化学式: C₈H₁₆N₂O₂S
• mdl: MFCD00544091
• 分子量: 204.293
• InChiKey: MTKKSVZRQYFVME-UHFFFAOYSA-N

物化性质

• 沸点：
  498.6±30.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  bis(2-acetylaminoethyl) sulfide 在 双氧水 、 溶剂黄146 作用下， 反应 24.0h， 以97%的产率得到bis(trifluoroacetylaminoethyl)sulfoxide
  参考文献：
  名称：

  含氮二乙基亚砜的合成及防辐射活性

  摘要：

  这项工作继续了之前对二乙基亚砜衍生物生物活性的研究 [1]，并报告了二乙基亚砜及其在邻位具有含氮取代基的类似物的合成和辐射防护特性。由于发现 [1] 双 [2-(n-butyrylamino)ethyl] sulfoxide (I) 具有辐射防护特性，因此合成该化合物的未报道的杂环类似物和在邻位含有其他酰氨基的二乙基亚砜是有意义的. N-乙酰基-(II)和N-u'氟乙酰基-(III)亚砜通过用过乙酸氧化相应的硫化物而获得。已确定最初的 N-酰基二乙基硫醚 (IV, V) 更方便地通过相应酸的酸酐酰化双 (2-氨基乙基) 硫化物获得，而不是像 [1] 中的氯酸酐（硫化物 IV 以前仅作为反应副产物以痕量形式分离） N-乙酰乙胺与HzS [2]）。使用中间体 N-（正丁酰基）硫代吗啉 (VII) 的两步法从硫代吗啉获得杂环亚砜 (VI)。

  DOI：

  10.1007/bf02464681
• 作为产物：
  描述：

  N,N'-(二硫代二乙烯)二乙酰胺 在 磷酸二乙酯钠盐 作用下， 以 四氢呋喃 为溶剂， 反应 144.0h， 生成 bis(2-acetylaminoethyl) sulfide
  参考文献：
  名称：

  Phosphonic Acids. VII. The Reaction of Sodium Diethyl Phosphonate with Organic Disulfides

  摘要：

  DOI：

  10.1021/ja00894a019

文献信息

• Kuhn et al., Chemische Berichte, 1953, vol. 86, p. 468,470
  作者：Kuhn et al.

  DOI：——

  日期：——
• Sulfur-containing carboxylic acids. 5. Synthesis and structure of dialkyl sulfides and dialkyl sulfoxides with vicinal carboxyl or acylamino groups
  作者：T. P. Vasil'eva、A. O. Mozzhukhin、M. Yu. Antipin、Yu. T. Struchkov

  DOI：10.1007/bf00864333

  日期：1992.8

  Bifunctional sulfides and sulfoxides containing carboxy, carbamoyl, or acylamino groups in the beta-position are synthesized, and their IR spectra were studied. An unusual decrease in the.frequencies of the carbonyl vibrations (by 20-34 cm-1) was found for thiodipropionic acid, its amides, and bis(beta-acylaminoethyl) sulfides by comparison with the corresponding sulfoxides. The low-frequency shift of the CO band in these carbonylsulfides was not, as expected, associated with the intramolecular S...O coordination, since the x-ray structural investigation of thiodipropionic acid and bis(2-trifluoroacetylaminoethyl) sulfide did not show short intra- and intermolecular contacts involving the sulfur atom. Both structures contain intermolecular hydrogen bonds (C-O...HO or C=O...HN).
• PHOTORESIST COMPOSITIONS AND PATTERN FORMATION METHODS
  申请人：ROHM AND HAAS ELECTRONIC MATERIALS LLC

  公开号：US20220043342A1

  公开（公告）日：2022-02-10

  Disclosed herein is a photoresist composition, comprising a first polymer formed by free radical polymerization, the first polymer comprising polymerized units formed from a monomer comprising an ethylenically unsaturated double bond and an acid-labile group; a photoacid generator; a quencher of formula (1): wherein: R 1 is independently a hydrogen atom, C 1 -C 20 linear, C 3 -C 20 branched, or C 3-20 cyclic alkyl, the alkyl optionally comprising an —O— group other than at an alpha-position with respect to the amide C(O), or C 6 -C 20 aryl; R 2 is independently a hydrogen atom, C 1 -C 20 linear, C 3 -C 20 branched, or C 3 -C 20 cyclic alkyl, or C 6 -C 20 aryl; L is C 1 -C 20 linear or C 3 -C 20 branched alkylene comprising one or more heteroatom-containing groups independently selected from —O—, —S—, or —N(R 3 )—, wherein R 3 is selected from a hydrogen atom or C 1 -C 20 linear or C 3 -C 20 branched or cyclic alkyl; each of R 1 , R 2 , and L may independently be substituted or unsubstituted; wherein the quencher is free of crosslinkable groups; and a solvent.
• <b>Phosphonic Acids. VII. The Reaction of Sodium Diethyl Phosphonate with Organic Disulfides</b>
  作者：Ronald G. Harvey、Herbert I. Jacobson、Elwood V. Jensen

  DOI：10.1021/ja00894a019

  日期：1963.6
• Synthesis and radioprotective activity of nitrogen-containing diethylsulfoxides
  作者：T. P. Vasil'eva、N. I. Lisina

  DOI：10.1007/bf02464681

  日期：1997.1

  derivatives [1] and reports on the synthesis and radioprotective properties of diethylsulfoxide and its analogs having nitrogen-containing substituents in the vicinal position. Since it was found [1] that bis[2-(n-butyrylamino)ethyl]sulfoxide (I) possesses radioprotective properties, it was of interest to synthesize an unreported heterocyclic analog of this compound and diethylsulfoxides containing other

  这项工作继续了之前对二乙基亚砜衍生物生物活性的研究 [1]，并报告了二乙基亚砜及其在邻位具有含氮取代基的类似物的合成和辐射防护特性。由于发现 [1] 双 [2-(n-butyrylamino)ethyl] sulfoxide (I) 具有辐射防护特性，因此合成该化合物的未报道的杂环类似物和在邻位含有其他酰氨基的二乙基亚砜是有意义的. N-乙酰基-(II)和N-u'氟乙酰基-(III)亚砜通过用过乙酸氧化相应的硫化物而获得。已确定最初的 N-酰基二乙基硫醚 (IV, V) 更方便地通过相应酸的酸酐酰化双 (2-氨基乙基) 硫化物获得，而不是像 [1] 中的氯酸酐（硫化物 IV 以前仅作为反应副产物以痕量形式分离） N-乙酰乙胺与HzS [2]）。使用中间体 N-（正丁酰基）硫代吗啉 (VII) 的两步法从硫代吗啉获得杂环亚砜 (VI)。