4,9-dichloro-[3]phenanthrol | 109406-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 4,9-dichloro-[3]phenanthrol
• 英文别名: 4,9-Dichlor-[3]phenanthrol；4,9-Dichlorophenanthren-3-ol；4,9-dichlorophenanthren-3-ol
• CAS: 109406-94-2
• 化学式: C₁₄H₈Cl₂O
• 分子量: 263.123
• InChiKey: SMUHUYXJSQTXCP-UHFFFAOYSA-N

物化性质

• 熔点：
  141-142 °C(Solvent: Acetic acid)
• 沸点：
  441.6±25.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,9-dichloro-[3]phenanthrol 在 吡啶 、 盐酸 、 tin 、 copper(II) sulfate 、 溶剂黄146 作用下， 生成 3-methoxy-9-cyanophenanthrene
  参考文献：
  名称：

  Prevalence and severity of substance misuse among referrals to a local forensic service

  摘要：

  Substance misuse is frequently present alongside mental illness and personality disorder, complicating all aspects of management. We describe self-reported levels of substance misuse in referrals to a forensic psychiatry service, to establish degrees of dependency and co-morbidity with other diagnostic categories and to report the implications for treatment. There were 146 (70%) of 209 consecutive referrals who completed a semi-structured questionnaire, including the Alcohol Use Disorders Identification Test (AUDIT), Severity of Alcohol Dependency Questionnaire (SADQ), Alcohol Problem Questionnaire (APQ) and, for frequent users of opiates or stimulants, the Severity of Dependence Scales (SDS). Psychiatric diagnoses were made from clinical assessment using the International Classification of Diseases (World Health Organization, 1992). ICD-10 diagnoses of substance misuse were found in 83 (57%) subjects. A combination of mental illness and a substance misuse diagnosis was found in 54 (37%). The subgroup accepted into forensic psychiatric services was found to have higher levels of co-morbidity, although levels of dependency were low. Forensic services need expertise in assessing drug-related morbidity; in motivational interviewing and other techniques for encouraging change; and in consolidating recovery.

  DOI：

  10.1080/09585180110057154
• 作为产物：
  描述：

  3-菲醇 在 磺酰氯 作用下， 生成 4,9-dichloro-[3]phenanthrol
  参考文献：
  名称：

  Prevalence and severity of substance misuse among referrals to a local forensic service

  摘要：

  Substance misuse is frequently present alongside mental illness and personality disorder, complicating all aspects of management. We describe self-reported levels of substance misuse in referrals to a forensic psychiatry service, to establish degrees of dependency and co-morbidity with other diagnostic categories and to report the implications for treatment. There were 146 (70%) of 209 consecutive referrals who completed a semi-structured questionnaire, including the Alcohol Use Disorders Identification Test (AUDIT), Severity of Alcohol Dependency Questionnaire (SADQ), Alcohol Problem Questionnaire (APQ) and, for frequent users of opiates or stimulants, the Severity of Dependence Scales (SDS). Psychiatric diagnoses were made from clinical assessment using the International Classification of Diseases (World Health Organization, 1992). ICD-10 diagnoses of substance misuse were found in 83 (57%) subjects. A combination of mental illness and a substance misuse diagnosis was found in 54 (37%). The subgroup accepted into forensic psychiatric services was found to have higher levels of co-morbidity, although levels of dependency were low. Forensic services need expertise in assessing drug-related morbidity; in motivational interviewing and other techniques for encouraging change; and in consolidating recovery.

  DOI：

  10.1080/09585180110057154

文献信息

• Prevalence and severity of substance misuse among referrals to a local forensic service
  作者：Sarah Isherwood、Deborah Brooke

  DOI：10.1080/09585180110057154

  日期：2001.1

  Substance misuse is frequently present alongside mental illness and personality disorder, complicating all aspects of management. We describe self-reported levels of substance misuse in referrals to a forensic psychiatry service, to establish degrees of dependency and co-morbidity with other diagnostic categories and to report the implications for treatment. There were 146 (70%) of 209 consecutive referrals who completed a semi-structured questionnaire, including the Alcohol Use Disorders Identification Test (AUDIT), Severity of Alcohol Dependency Questionnaire (SADQ), Alcohol Problem Questionnaire (APQ) and, for frequent users of opiates or stimulants, the Severity of Dependence Scales (SDS). Psychiatric diagnoses were made from clinical assessment using the International Classification of Diseases (World Health Organization, 1992). ICD-10 diagnoses of substance misuse were found in 83 (57%) subjects. A combination of mental illness and a substance misuse diagnosis was found in 54 (37%). The subgroup accepted into forensic psychiatric services was found to have higher levels of co-morbidity, although levels of dependency were low. Forensic services need expertise in assessing drug-related morbidity; in motivational interviewing and other techniques for encouraging change; and in consolidating recovery.