((1R,3Ξ,4Ξ)-3,4-dihydroxy-2,2,3-trimethyl-cyclopentyl)-acetic acid | 122338-13-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((1R,3Ξ,4Ξ)-3,4-dihydroxy-2,2,3-trimethyl-cyclopentyl)-acetic acid
• 英文别名: ((1R,3Ξ,4Ξ)-3,4-Dihydroxy-2,2,3-trimethyl-cyclopentyl)-essigsaeure；(+)-((1R,3Ξ,4Ξ)-3,4-Dihydroxy-2,2,3-trimethyl-cyclopentyl)-essigsaeure；1.1.2-Trimethyl-cyclopentandiol-(2.3)-essigsaeure-(5)；3.4-Dioxy-2.2.3-trimethyl-cyclopentylessigsaeure；Dioxydihydro-α-campholensaeure；2-[(1R)-3,4-dihydroxy-2,2,3-trimethylcyclopentyl]acetic acid
• CAS: 122338-13-0
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: SFOFPZCSBIJHFV-AFKSGGFBSA-N

物化性质

• 熔点：
  147 °C
• 沸点：
  333.9±22.0 °C(Predicted)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.76
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  ((1R,3Ξ,4Ξ)-3,4-dihydroxy-2,2,3-trimethyl-cyclopentyl)-acetic acid 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Delepine, Bulletin de la Societe Chimique de France, 1937, vol. <5> 4, p. 1145

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium permanganate 作用下， 生成 ((1R,3Ξ,4Ξ)-3,4-dihydroxy-2,2,3-trimethyl-cyclopentyl)-acetic acid
  参考文献：
  名称：

  Increased levels of advanced glycosylation end products in the kidney and liver from spontaneously diabetic Chinese hamsters determined by immunochemical assay

  摘要：

  Increased levels of advanced glycosylation end products (AGEs) have been reported in tissues in association with diabetes mellitus. Thus, we measured tissue AGE levels and detected an accumulation of AGEs in the kidney and liver from spontaneously diabetic Chinese hamsters (CHAD) to determine the relationship between AGEs and diabetes mellitus. Diabetic CHAD aged 12 to 13 months were studied together with age-matched nondiabetic CHAD. We used an AGE-specific noncompetitive enzyme-linked immunosorbent assay (ELISA) with polyclonal anti-AGE-bovine serum albumin (BSA) antibody to measure tissue AGE levels. The samples extracted from the kidney and liver obtained from diabetic and nondiabetic CHAD reacted with anti-AGE-BSA antibody. When the absorbance of standard AGE-BSA (0.1 mu g/mL) was expressed as 1 U, AGE levels in the kidney and liver from diabetic CHAD were significantly increased as compared with nondiabetic CHAD (kidney, 0.26 +/- 0.05 v 0.10 +/- 0.03 U/mu g protein, P < .01; liver, 0.20 +/- 0.03 v 0.09 +/- 0.02 U/mu g protein, P < .01). Positive AGE staining was observed in the renal cortex, especially in the tubules of diabetic CHAD, but little AGE staining was observed in the glomerulus by the immunohistochemical study. AGE staining was diffuse in the hepatocytes. These AGE levels were significantly correlated with fasting plasma glucose and glycated hemoglobin (P < .01, respectively). In conclusion, we have confirmed that AGE structures were expressed in the kidney and liver from CHAD, and these AGE levels were increased in diabetic CHAD. AGE staining was observed in the renal tubules and hepatocytes. Tissue AGE levels were positively correlated with glycemic control in CHAD. Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0026-0495(00)80029-3

文献信息

• Tiemann, Chemische Berichte, 1895, vol. 28, p. 2174
  作者：Tiemann

  DOI：——

  日期：——
• Tiemann, Chemische Berichte, 1896, vol. 29, p. 3007
  作者：Tiemann

  DOI：——

  日期：——
• Critical reactions for the hydrazine vapor detonations
  作者：L. Catoire、J. Luche、G. Dupré、C. Paillard

  DOI：10.1007/pl00004070

  日期：2001.7

  A detailed kinetic model devoted to the hydrazine vapor detonation has been built. It consists of 33 reversible reactions and 13 species. A reduced kinetic model has been proposed by using the Principal Component Analysis of matrix F (PCAF) method as implemented ill KINALC. It is constituted of 26 reactions anti 11 species. This: model has been shown to be valid ol er a pressure range of 0.1 to 10 atm. However, the predictions of the models are significantly affected by changes: in the enthalpy of formation of N2H3. With the help of the full kinetic model, a value of A, the proportionality factor in the ZND model between the induction distance in the detonation cell size, of 27.5 +/- 3.0 has been derived if one considers that the collision efficiency of N2H4 on the thermal decomposition of hydrazine is equal to the orle of N-2. The value of A for pure hydrazine detonation is: shown to be strongly dependent on the value of the collision efficiency of N2H4.
• Tiemann, Chemische Berichte, 1896, vol. 29, p. 129
  作者：Tiemann

  DOI：——

  日期：——
• Harispe,M.; Mea,D., Bulletin de la Societe Chimique de France, <hi>1962</hi>, p. 1340 - 1343
  作者：Harispe,M.、Mea,D.

  DOI：——

  日期：——