2-(4-phthalimidobutyl)-9-methoxy-5H<1>benzopyrano<4,3-c>pyridazin-3(2H)one | 147032-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(4-phthalimidobutyl)-9-methoxy-5H<1>benzopyrano<4,3-c>pyridazin-3(2H)one
• 英文别名: 2-[4-(9-methoxy-3-oxo-5H-chromeno[4,3-c]pyridazin-2-yl)butyl]isoindole-1,3-dione
• CAS: 147032-04-0
• 化学式: C₂₄H₂₁N₃O₅
• 分子量: 431.448
• InChiKey: MMXHMRVIKDYWGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-phthalimidobutyl)-9-methoxy-5H<1>benzopyrano<4,3-c>pyridazin-3(2H)one 在 盐酸 、 一水合肼 作用下， 生成 2-(4-aminobutyl)-9-methoxy-5H<1>benzopyrano<4,3-c>pyridazin-3(2H)one hydrochloride
  参考文献：
  名称：

  Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

  摘要：

  A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in die ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.

  DOI：

  10.1016/0223-5234(92)90116-i
• 作为产物：
  描述：

  4a,5-Dihydro-9-methoxy-2H-(1)benzopyrano(4,3-c)pyridazin-3(4H)-one 在 四氯苯醌 、 potassium carbonate 作用下， 以 xylene 为溶剂， 反应 78.0h， 生成 2-(4-phthalimidobutyl)-9-methoxy-5H<1>benzopyrano<4,3-c>pyridazin-3(2H)one
  参考文献：
  名称：

  Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

  摘要：

  A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in die ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.

  DOI：

  10.1016/0223-5234(92)90116-i

文献信息

• Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity
  作者：G Cignarella、D Barlocco、S Villa、MM Curzu、GA Pinna、A Lavezzo、A Bestetti

  DOI：10.1016/0223-5234(92)90116-i

  日期：1992.11

  A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in die ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.