3,3'-(1,4-phenylenebis(oxy))bis(propane-1,2-diol) | 7734-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,3'-(1,4-phenylenebis(oxy))bis(propane-1,2-diol)
• 英文别名: 1,4-bis-(2,3-dihydroxy-propoxy)-benzene；1,4-Bis-(2,3-dihydroxy-propoxy)-benzol；3-[4-(2,3-Dihydroxypropoxy)phenoxy]propane-1,2-diol
• CAS: 7734-54-5
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: PUCRCVZEFZKZAL-UHFFFAOYSA-N

物化性质

• 熔点：
  122-124 °C
• 沸点：
  519.9±45.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,3'-(1,4-phenylenebis(oxy))bis(propane-1,2-diol) 在 正丁基锂 、 氢溴酸 、 1,8-双二甲氨基萘 、 溶剂黄146 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 8.83h， 生成 [(4R)-4-methoxy-5-[4-[(2R)-2-methoxy-5-trimethylsilylpent-4-ynoxy]phenoxy]pent-1-ynyl]-trimethylsilane
  参考文献：
  名称：

  全合成佛波唑B.

  摘要：

  已经实现了有效的和高度收敛的有效的抗肿瘤药phorboxazole B的全合成。该合成方法的合成策略为：1）高效的底物控制的氢化反应，以构建官能化的顺式-四氢吡喃单元；2）重复的巴豆基加成反应，以合成含有交替的羟基和甲基取代基的链段；3）Hg（OAc）2 / I 2诱导的环化以建立顺式-四氢吡喃部分；4）在Mukaiyama aldol反应中的1，3-不对称诱导以在C9和C3处提供立体异构中心；5）探索Still-Gennari烯化反应以完成佛波唑唑B的大环内酯环。

  DOI：

  10.1002/chem.200500892
• 作为产物：
  描述：

  1,4-二(丙-2-烯氧基)苯 在 potassium carbonate potassium osmate(VI) 、 氢化奎宁 1,4-(2,3-二氮杂萘)二醚 、 potassium hexacyanoferrate(III) 作用下， 以 叔丁醇 为溶剂， 反应 15.0h， 以66%的产率得到3,3'-(1,4-phenylenebis(oxy))bis(propane-1,2-diol)
  参考文献：
  名称：

  全合成佛波唑B.

  摘要：

  已经实现了有效的和高度收敛的有效的抗肿瘤药phorboxazole B的全合成。该合成方法的合成策略为：1）高效的底物控制的氢化反应，以构建官能化的顺式-四氢吡喃单元；2）重复的巴豆基加成反应，以合成含有交替的羟基和甲基取代基的链段；3）Hg（OAc）2 / I 2诱导的环化以建立顺式-四氢吡喃部分；4）在Mukaiyama aldol反应中的1，3-不对称诱导以在C9和C3处提供立体异构中心；5）探索Still-Gennari烯化反应以完成佛波唑唑B的大环内酯环。

  DOI：

  10.1002/chem.200500892

文献信息

• The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies
  作者：Daniel M. Gill、Ana Paula R. Povinelli、Gabriel Zazeri、Sabrina A. Shamir、Ayman M. Mahmoud、Fiona L. Wilkinson、M. Yvonne Alexander、Marinonio L. Cornelio、Alan M. Jones

  DOI：10.1039/d0md00366b

  日期：——

  The conceptual technology of small molecule glycomimetics, exemplified by compounds C1–4, has shown promising protective effects against lipid-induced endothelial dysfunction.

  小分子糖类模拟物的概念技术，例如化合物C1-4，已显示出对脂质诱导的内皮功能障碍具有有希望的保护效果。
• Thermoplastic saturated norbornene group polymer composition
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0498564A2

  公开（公告）日：1992-08-12

  Provided is a resin composition based on a thermoplastic saturated norbornene group polymer which is excellent in adhesion to the recording film of optical disks and adhesion to a hard coating film or a protective film formed by coating an acrylic ultraviolet curing coating material or like films without deteriorating excellent heat resistance and transparency inherent to thermoplastic saturated norbornene group polymers. Also provided are optical disk substrates and optical disks by using said composition. A composition comprising a thermoplastic saturated norbornene group polymer and a partially etherified product of a polyhydric alcohol having 3 or more hydroxyl groups incorporated thereinto. An optical disk substrate formed of said composition and an optical disk comprising said optical disk substrate and an information recording film and/or a light reflecting film and a protective film laminated thereon.

  本发明提供了一种基于热塑性饱和降冰片烯基聚合物的树脂组合物，该组合物与光盘记录膜的粘合性以及与硬涂膜或通过涂覆丙烯酸紫外线固化涂层材料或类似薄膜而形成的保护膜的粘合性极佳，且不会降低热塑性饱和降冰片烯基聚合物固有的优异耐热性和透明度。此外，还提供了使用所述组合物的光盘基板和光盘。 一种组合物，由热塑性饱和降冰片烯基聚合物和含有 3 个或 3 个以上羟基的多元醇的部分醚化产物组成。由所述组合物形成的光盘基板，以及由所述光盘基板和信息记录膜和/或光反射膜以及层压在其上的保护膜组成的光盘。
• RESIN COMPOSITION CONTAINING VINYLIC CYCLIC HYDROCARBON POLYMER AND PRODUCT OF MOLDING THEREOF
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP1000974A1

  公开（公告）日：2000-05-17

  A molded or formed product obtained by molding or forming a resin composition comprising (A) at least one vinyl cyclic hydrocarbon polymer selected from the group consisting of hydrogenated products of aromatic vinyl polymers, vinylcyclohexene polymers or hydrogenated products thereof, and vinylcyclohexane polymers, and (B) at least one substance selected from the group consisting of compounding additives incompatible with the polymer, organic compounds having at least one alcoholic hydroxyl group and at least one ether linkage, and organic compounds having at least one alcoholic hydroxyl group and at least one ester linkage, wherein the initial light transmittance (a) of the molded or formed product at an optional wavelength within a range of 400 to 800 nm and the light transmittance (b) of the molded or formed product after the molded or formed product is held for 1,000 hours in an atmosphere of 65°C in temperature and 90% in relative humidity satisfy the relationship of the equation (1):[(b)/(a)] x 100 ≥ 70 and a resin composition.

  一种通过模塑或成型树脂组合物获得的模塑或成型产品，该树脂组合物包含(A)至少一种乙烯基环烃聚合物，该聚合物选自由芳香族乙烯基聚合物的氢化产物、乙烯基环己烯聚合物或其氢化产物和乙烯基环己烷聚合物组成的组；以及(B)至少一种物质，该物质选自由与聚合物不相容的复合添加剂、具有至少一个醇羟基和至少一个醚键的有机化合物组成的组；以及具有至少一个醇羟基和至少一个酯键的有机化合物、其中模塑或成型产品在 400 至 800 纳米范围内的任选波长下的初始透光率 (a) 和模塑或成型产品在温度为 65°C 和相对湿度为 90% 的环境中保持 1,000 小时后的透光率 (b) 满足公式 (1) 的关系：[(b)/(a)] x 100 ≥ 70 和树脂成分。
• Resin composition and molded or formed product comprising vinyl cyclic hydrocarbon polymer
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP1413601A2

  公开（公告）日：2004-04-28

  A molded or formed product obtained by molding or forming a resin composition comprising (A) at least one vinyl cyclic hydrocarbon polymer selected from the group consisting of hydrogenated products of aromatic vinyl polymers, vinylcyclohexene polymers or hydrogenated products thereof, and vinylcyclohexane polymers, and (B) at least one substance selected from the group consisting of organic compounds having at least one alcoholic hydroxyl group and at least one ether linkage, and organic compounds having at least one alcoholic hydroxyl group and at least one ester linkage, wherein the initial light transmittance (a) of the molded or formed product at an optional wavelength within a range of 400 to 800 nm and the light transmittance (b) of the molded or formed product after the molded or formed product is held for 1,000 hours in an atmosphere of 65°C in temperature and 90% in relative humidity satisfy the relationship of the equation (1):[(b)/(a)] x 100 ≥ 70 and a resin composition.

  一种通过模塑或成型树脂组合物获得的模塑或成型产品，该树脂组合物包含 (A) 至少一种乙烯基环烃聚合物，选自由芳香族乙烯基聚合物的氢化产物、乙烯基环己烯聚合物或其氢化产物和乙烯基环己烷聚合物组成的组，以及 (B) 至少一种物质，选自由以下组成的组 具有至少一个醇羟基和至少一个醚键的有机化合物，以及具有至少一个醇羟基和至少一个酯键的有机化合物，其中模塑或成型产品在 400 至 800 纳米范围内任选波长的初始透光率(a)，以及模塑或成型产品在温度为 65°C、相对湿度为 90%的环境中保持 1,000 小时后的透光率(b)满足式(1)的关系：[(b)/(a)] x 100 ≥ 70 和树脂成分。
• Resin composition comprising vinyl cyclic hydrocarbon polymer
  申请人：——

  公开号：US20020032264A1

  公开（公告）日：2002-03-14

  A molded or formed product obtained by molding or forming a resin composition comprising (A) at least one vinyl cyclic hydrocarbon polymer selected from the group consisting of hydrogenated products of aromatic vinyl polymers, vinylcyclohexene polymers or hydrogenated products thereof, and vinylcyclohexane polymers, and (B) at least one substance selected from the group consisting of compounding additives incompatible with the polymer, organic compounds having at least one alcoholic hydroxyl group and at least one ether linkage, and organic compounds having at least one alcoholic hydroxyl group and at least one ester linkage, wherein the initial light transmittance (a) of the molded or formed product at an optional wavelength within a range of 400 to 800 nm and the light transmittance (b) of the molded or formed product after the molded or formed product is held for 1,000 hours in an atmosphere of 65° C. in temperature and 90% in relative humidity satisfy the relationship of the equation (1): [( b )/( a )]×100≧70  (1) and a resin composition.

  一种通过模塑或成型树脂组合物获得的模塑或成型产品，该树脂组合物包含(A)至少一种乙烯基环烃聚合物，该聚合物选自由芳香族乙烯基聚合物的氢化产物、乙烯基环己烯聚合物或其氢化产物和乙烯基环己烷聚合物组成的组，以及(B)至少一种物质，该物质选自由与聚合物不相容的复合添加剂组成的组、具有至少一个醇羟基和至少一个醚键的有机化合物，以及具有至少一个醇羟基和 至少一个酯键的有机化合物，其中模制或成型产品在 400 至 800 纳米范围内的任选波长下的初始透光率 (a) 和模制或成型产品在 65°C.温度和 90% 相对湿度的环境中保持 1 000 小时后，其透光率 (b) 符合公式 (1) 的关系： [( b )/( a ) ]×100≧70 (1) 和一种树脂组合物。