ethylaminoacetohydrazide | 33207-20-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethylaminoacetohydrazide
• 英文别名: N-Aethyl-glycin-hydrazid；2-(Ethylamino)acetohydrazide
• CAS: 33207-20-4
• 化学式: C₄H₁₁N₃O
• 分子量: 117.151
• InChiKey: KYVJWDBLFYJOIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  282.1±23.0 °C(Predicted)
• 密度：
  1.036±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3,5,6-四甲基苯甲醛 、 ethylaminoacetohydrazide 以 乙醇 为溶剂， 生成 2-(ethylamino)-N-[(2,3,5,6-tetramethylphenyl)methylideneamino]acetamide
  参考文献：
  名称：

  Tajana; Portioli; Nardi, Bollettino Chimico Farmaceutico, 1979, vol. 118, # 7, p. 397 - 406

  摘要：

  DOI：
• 作为产物：
  描述：

  乙基N-乙基甘氨酸酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 ethylaminoacetohydrazide
  参考文献：
  名称：

  抗菌硝基呋喃衍生物。2.5-硝基-2-呋喃甲醛氨基乙hydr。

  摘要：

  DOI：

  10.1021/jm00289a019

文献信息

• Catto, A.; Cappelletti, R.; Leonardi, A., Farmaco, Edizione Scientifica, 1983, vol. 38, # 8, p. 559 - 570
  作者：Catto, A.、Cappelletti, R.、Leonardi, A.、Maggi, F.、Tajana, A.、Nardi, D.

  DOI：——

  日期：——
• Catto; Cappelletti; Leonardi, Farmaco, Edizione Scientifica, 1983, vol. 38, # 1, p. 45 - 56
  作者：Catto、Cappelletti、Leonardi、et al.

  DOI：——

  日期：——
• Conformational analysis of hydrazones.1H dynamic nuclear magnetic resonance and solvent effects in aryl- and 2-furylaldehyde ethylaminoacetylhydrazones
  作者：Rois Benassi、Adriano Benedetti、Ferdinando Taddei、Roberto Cappelletti、Dante Nardi、Alberto Tajana

  DOI：10.1002/mrc.1270200107

  日期：1982.9

  AbstractAryl‐ and 2‐furylaldehyde ethylaminoacetylhydrazones were examined in different solvents and over a wide temperature range with1H NMR in order to study their conformational properties. Nearly equal amounts of theE/Zisomers, relative to the CN bond, are present, even when the solvents and the substituents on the aldimino carbon produce small changes in the isomeric mixture. The activation parameters of the thermal isomerization process were measured, and the results are in the line with a lateral‐shift type mechanism, also supported by theoretical calculations on a model compound. No other internal process was noted from the low‐temperature spectral behaviour, and this was interpreted in terms of a highly biased equilibrium concerning the rotation around the C(O)N bond. Chemical shifts obtained in different solvents also enable the most stable arrangement of the whole molecule of these compounds to be postulated.
• CATTO, A.;CAPPELLETTI, R.;LEONARDI, A.;TAJANA, A.;MAGGI, F.;NARDI, D.;TAD+, FARMACO. ED. SCI., 1983, 38, N 1, 45-56
  作者：CATTO, A.、CAPPELLETTI, R.、LEONARDI, A.、TAJANA, A.、MAGGI, F.、NARDI, D.、TAD+

  DOI：——

  日期：——
• Tajana; Portioli; Nardi, Bollettino Chimico Farmaceutico, 1979, vol. 118, # 7, p. 397 - 406
  作者：Tajana、Portioli、Nardi、Magistretti

  DOI：——

  日期：——