1,3-Bis-(2-methoxy-phenyl)-pyrimidine-2,4,6-trione | 184589-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,3-Bis-(2-methoxy-phenyl)-pyrimidine-2,4,6-trione
• 英文别名: 1,3-Bis(2-methoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione；1,3-bis(2-methoxyphenyl)-1,3-diazinane-2,4,6-trione
• CAS: 184589-04-6
• 化学式: C₁₈H₁₆N₂O₅
• 分子量: 340.335
• InChiKey: WFUYPGVWLPYXHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-Bis-(2-methoxy-phenyl)-pyrimidine-2,4,6-trione 在 吡啶 、 溴 作用下， 以 乙醇 为溶剂， 生成 (3'aR,5'R,6'R,7'S,7'aR)-6',7'-dihydroxy-5'-(hydroxymethyl)-1,3-bis(2-methoxyphenyl)spiro[1,3-diazinane-5,2'-5,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-b]pyran]-2,4,6-trione
  参考文献：
  名称：

  Synthesis of Novel Galactopyranosyl‐Derived Spiro Barbiturates

  摘要：

  Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2, which on bromination give 5,5-dibromobarbituric acids 3. Reaction of alpha-D-galactose with these 5,5-dibromo barbituric acids afforded 2,3-alpha-D-galactopyrano-1,4-dioxo-7,9-diaza-spiro[4,5]deca-6,8,10-triones 4. The structures of the products have been assigned on the basis of H-1 NMR, C-13 NMR, FAB-MS, optical activity, and elemental analysis. The title compounds are found to have antibacterial and antifungal activities.

  DOI：

  10.1080/07328300601039328
• 作为产物：
  描述：

  丙二酸 、 1,3-二(2-甲氧基苯基)脲 在 乙酸酐 、 溶剂黄146 作用下， 以43%的产率得到1,3-Bis-(2-methoxy-phenyl)-pyrimidine-2,4,6-trione
  参考文献：
  名称：

  Synthesis of Novel Galactopyranosyl‐Derived Spiro Barbiturates

  摘要：

  Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2, which on bromination give 5,5-dibromobarbituric acids 3. Reaction of alpha-D-galactose with these 5,5-dibromo barbituric acids afforded 2,3-alpha-D-galactopyrano-1,4-dioxo-7,9-diaza-spiro[4,5]deca-6,8,10-triones 4. The structures of the products have been assigned on the basis of H-1 NMR, C-13 NMR, FAB-MS, optical activity, and elemental analysis. The title compounds are found to have antibacterial and antifungal activities.

  DOI：

  10.1080/07328300601039328

文献信息

• A facile synthesis of some new pyrimidine-2,4,6-triones analogs and their O-β-D-glucosides P-glycoprotein and antioxidant, antimicrobial study, blood–brain barrier, cytochrome p450 enzyme activity prediction
  作者：Kishor M. Hatzade、Ajay M. Ghatole、Pravin K. Gaidhane、Mahesh K. Gaidhane、Gunwant P. Gadekar

  DOI：10.1007/s00044-020-02649-7

  日期：2021.1

  -chromen-4-one 1 has resulted in the formation of new 5-[(7-hydroxy-4-oxo-4 H -chromen-3-yl)methylene]-1,3-disubstitutedpyrimidine-2, 4, 6 (1 H , 2 H , 3 H )-triones 3a – g . These compounds have used for the synthesis of medicinally important 5-[(7- o - β - d -glucopyranosyloxy-4-oxo-4 H -chromen-3-yl)methylene]-1,3-disubstitutedpyrimidine-2,4,6(1 H ,2 H ,3 H )-triones 6a – g using α-acetobromoglucose (ACBG) as

  3-formyl-4 H -chromen-4-one 1 将几个 1,3-di取代pyrimidine-2,4,6(1 H ,2 H ,3 H )-triones 2a – g 缩合形成新的 5-[(7-hydroxy-4-oxo-4 H -chromen-3-yl)methylene]-1,3-di取代pyrimidine-2, 4, 6 (1 H , 2 H , 3 H )-triones 3a – G 。这些化合物已用于合成医学上重要的 5-[(7-o-β-d-吡喃葡萄糖基氧基-4-oxo-4 H -chromen-3-yl)methylene]-1,3-di取代pyrimidine-2,4, 6(1 H ,2 H ,3 H )-triones 6a – g 使用 α-乙酰溴葡萄糖 (ACBG) 作为葡糖基化剂，在十二烷基三甲基溴化铵 (DTMAB) 作为相转移催化剂的情况下。产物结构经
• Synthesis and Antibacterial Activities of 1,2,3,4,6,7,8,9-octahydro-1,3,7,9-tetraphenyl 5-pyrrolo-2,4,6,8-tetraoxo-10H, 5H pyrido[2,3-d; 6,5-d']dipyrimidine
  作者：T. Suresh、R. Nandha kumar、P. S. Mohan

  DOI：10.1515/hc.2003.9.2.203

  日期：2003.1

  :l). The yield was 74 % and its melting point above 300 °C. The IR spectrum showed strong absorption bands at 1683 cm" for-N-CO-C groups, 1654 cm" forN-CO-N groups and 3100 3350 cm" for-NH groups. The 'H-NMR spectrum revealed a sharp singlet at δ 6.6 for the C5 methine proton. The other singlets at δ 8.5 and δ 13.1 were attributed to pyrrole -NH and pyrido -NH respectively. All the other twenty-three

  用吡咯-2-甲醛和氨水在无水乙醇中处理 1,3-二芳基巴比妥酸两小时，得到所需的 l,2,3,4,6,7,8,9-octahydro-l,3,7, 9-四苯基 5-pyrrolo-2,4,6,8-tetraoxo-10//, 5Hpyrido[2,3-d; 6,5-i/']双嘧啶。还筛选了所有合成的化合物对伤寒沙门氏菌和嗜水气单胞菌的抗菌活性。引言 开发合成氮杂环特别是双环吡啶的新方法在有机化学中具有相当重要的意义。合成这些杂环的开创性工作通过各种途径完成，“由于它们具有广谱的生理和药理特性、仿生氧化、抗菌、抗肿瘤活性”等。巴比妥酸已被用作制备许多带有嘧啶核的杂环的原料。然而，较早的方法无法提供 pyrido[2,3-i/; 6,5-if ]二嘧啶在 C5 位置具有取代基。本文通过 1,3-二芳基巴比妥酸与胺和醛在无水乙醇中在回流温度下反应合成了新型吡啶并[2,3-J;6,5-i/]二嘧啶衍生物。两个小时。实验
• AMINOMETHYLENE DERIVATIVES AND ULTRAVIOLET ABSORBER COMPRISING THE SAME
  申请人：CHEMIPRO KASEI KAISHA, LIMITED

  公开号：EP0950655A1

  公开（公告）日：1999-10-20

  The present invention provides an aminomethylene derivative represented by general formula (I): wherein A is a cyclic oxo group selected from the group consisting of following general formulae (a), (b), (c), (d) and (e): wherein R1, R2, R3, R4 and R5 each independently represent H, an alkyl group or the like; R6, R7 and R8 each independently represent an alkyl group or the like; R1 and R2 or R7 and R8 may combine with each other to form a tetramethylene group or the like; R represents an alkyl group optionally containing OH or O; and n is an integer of 0 to 4, a process for the same, and the use thereof. The derivatives have an excellent ultraviolet absorption ability and a high optical stability.

  本发明提供一种由通式(I)表示的亚氨基亚甲基衍生物： 其中 A 是选自以下通式（a）、（b）、（c）、（d）和（e）所组成的组的环状氧代基团： 其中 R1、R2、R3、R4 和 R5 各自独立地代表 H、烷基或类似基团；R6、R7 和 R8 各自独立地代表烷基或类似基团；R1 和 R2 或 R7 和 R8 可相互结合形成四亚甲基或类似基团；R 代表任选含有 OH 或 O 的烷基；n 为 0 至 4 的整数。这些衍生物具有出色的紫外线吸收能力和较高的光学稳定性。
• Kumar, R. Nandha; Suresh; Magesh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 1, p. 184 - 186
  作者：Kumar, R. Nandha、Suresh、Magesh、Mohan

  DOI：——

  日期：——
• US6114546A
  申请人：——

  公开号：US6114546A

  公开（公告）日：2000-09-05