2′-(2,5-dihydrophenyl)ethanol | 13398-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2′-(2,5-dihydrophenyl)ethanol
• 英文别名: 2,5-Dihydroxyphenethylalkohol；2,5-dihydroxy-phenethyl alcohol；2,5-Dihydroxy-phenaethylalkohol；2-(2-Hydroxyethyl)benzene-1,4-diol
• CAS: 13398-95-3
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: OQDDFOFVIFIUME-UHFFFAOYSA-N

物化性质

• 熔点：
  182 °C
• 沸点：
  130-150 °C(Press: 1 Torr)
• 密度：
  1.321±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  2′-(2,5-dihydrophenyl)ethanol 在 对甲苯磺酸 4-二甲氨基吡啶 、 草酰氯 、 氢氟酸 、 四丁基氟化铵 、 溶剂黄146 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 、 苯 为溶剂， 反应 74.8h， 生成 N-[(Z)-2-(2,5-二羟基苯基)乙烯基]甲酰胺
  参考文献：
  名称：

  Total synthesis of erbstatin

  摘要：

  DOI：

  10.1016/s0040-4039(00)85330-7
• 作为产物：
  描述：

  2,5-二羟基苯基乙酸GAMMA内酯 在 二异丁基氢化铝 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 3.0h， 生成 2′-(2,5-dihydrophenyl)ethanol
  参考文献：
  名称：

  Total synthesis of erbstatin

  摘要：

  DOI：

  10.1016/s0040-4039(00)85330-7

文献信息

• Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells
  作者：Zhenzhen Tian、Juanjuan Li、Shumiao Zhang、Zhishan Xu、Yuliang Yang、Deliang Kong、Hairong Zhang、Xingxing Ge、Junming Zhang、Zhe Liu

  DOI：10.1021/acs.inorgchem.8b01944

  日期：2018.9.4

  Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward normal cells. Confocal microscopy was employed for the first time to determine the cellular localization of the half-sandwich Ru complex.

  癌细胞与正常细胞之间的选择性差是癌症化学疗法的主要限制之一。溶酶体靶向的钌基复合物选择性地靶向肿瘤细胞，仅表现出对正常细胞相当弱的细胞毒性或无活性。首次使用共聚焦显微镜来确定半三明治Ru复合物的细胞定位。
• [EN] 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES<br/>[FR] DERIVES DE 1-(2-AMINO-BENZOL)-PIPERAZINE EN TANT QU'INHIBITEURS DE L'ABSORPTION DU GLYCOCOLLE POUR TRAITER DES PSYCHOSES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005023260A1

  公开（公告）日：2005-03-17

  A compound of formula (I) wherein the substituents are described in claim 1 for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

  具有式（I）的化合物，其中取代基如权利要求1中所述，用于治疗精神病、疼痛、记忆和学习中的神经退行性功能障碍、精神分裂症、痴呆症以及认知过程受损的其他疾病，如注意力缺陷障碍或阿尔茨海默病。
• Topical Delivery System for Antiaging and Skin Whitening Agents
  申请人：GUPTA SHYAM K.

  公开号：US20090074691A1

  公开（公告）日：2009-03-19

  This invention relates to certain hydroxyaryl alkanols, alkyl amines, alkyl amino acids, alkyl amino esters, and alkyl amino alkanols (“Hydroxyaryl compounds”) of formula (I). A method of topical application of said hydroxyaryl compounds is also disclosed. The treatment of certain enzyme dysfunctions that cause skin or hair condition such as darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; and malfunction of matrix metalloprotease group of enzymes with said hydroxyaryl compounds is also disclosed:

  本发明涉及公式（I）的某些羟基芳基丙醇、烷基胺、烷基氨基酸、烷基氨基酯和烷基氨基丙醇（“羟基芳基化合物”）。还公开了一种使用上述羟基芳基化合物的局部应用方法。本发明还公开了使用上述羟基芳基化合物治疗某些酶功能障碍，这些酶功能障碍导致皮肤或头发状况的异常，例如黑化的皮肤，包括老年斑、眼周黑眼圈和妊娠纹引起的皮肤色素沉着；与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小；过早的头发老化，包括脱发和白发；炎症，包括细胞内和细胞外炎症；皮肤衰老，包括皱纹和细纹；胶原蛋白流失，包括皮肤变薄和失去弹性；酪氨酸酶类酶的功能障碍；以及基质金属蛋白酶类酶的功能障碍。
• Polyester laminated film
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0053498A2

  公开（公告）日：1982-06-09

  The present invention provides a polyester laminated film which comprises a transparent layer (1) and a delustered layer (2) laminated at least on one side face of the transparent layer. The transparent layer is formed by a biaxially stretched polyester film mainly composed of polyethylene terephthalate, while the delustered layer is made of an at least uniaxially stretched polyester film which is mainly composed of a polyethylene terephthalate copolymer containing, as a copolymer composition, 1 to 20 mol.% of the delustered layer of or (wherein n is an integer from 2 to 140, and X represents or and which also contains inert inorganic particles (2') of 0.3 to 20 microns diameter in an amount 3 to 40% by weight of the delustered layer. Film according to the present invention as described above is roughened on the surface, and has excellent writability and transcribability by pencils, ink, indian ink, etc., combined with an excellent transparency, and therefore, is very useful for use as tracing films and the like.

  本发明提供了一种聚酯层压薄膜，它包括透明层（1）和至少在透明层一侧面上层压的除尘层（2）。透明层由主要由聚对苯二甲酸乙二醇酯组成的双轴拉伸聚酯薄膜构成，而除尘层由至少单轴拉伸聚酯薄膜制成，该聚酯薄膜主要由聚对苯二甲酸乙二醇酯共聚物组成，其共聚物成分中含有 1 至 20 mol.% 的除尘层，其中包括 或 (其中 n 为 2 至 140 的整数，X 代表 或 ），其中还含有直径为 0.3 至 20 微米的惰性无机颗粒 (2')，含量为除尘层重量的 3 至 40%。 根据上述本发明的薄膜表面粗糙，用铅笔、墨水、印度墨水等书写和誊写时具有极佳的可书写性和可誊写性，同时具有极佳的透明度，因此非常适合用作描图薄膜等。
• Amino-functional polyethers containing urea, biuret, thiourea, dithiobiuret, thioamide, and/or amide moieties in their backbone and urethane/urea prepolymers and polymers made therefrom
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0307964A2

  公开（公告）日：1989-03-22

  This invention relates to novel polymeric polyamines containing internal urea, biuret, thiourea, dithiobiuret, and/or thioamide moieties, and to polymers prepared therefrom. This invention also relates to novel isocyanate-functional prepolymers containing urea, biuret, amide, thiourea, dithiobiuret. and/or thioamide moieties and to polymers prepared therefrom.

  本发明涉及含有内脲基、双脲基、酰胺基、硫脲基、二硫代双脲基和/或硫代酰胺基的新型聚合物多胺，以及由其制备的聚合物。本发明还涉及含有脲、缩二脲、酰胺、硫脲、二硫代缩二脲和/或硫代酰胺分子的新型异氰酸酯功能预聚物，以及用其制备的聚合物。