(R)-5-Guanidino-2-[(Z)-3-(4-hydroxy-phenyl)-acryloylamino]-pentanoic acid [2-(2-amino-ethoxy)-ethyl]-amide | 632323-92-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-5-Guanidino-2-[(Z)-3-(4-hydroxy-phenyl)-acryloylamino]-pentanoic acid [2-(2-amino-ethoxy)-ethyl]-amide
• CAS: 632323-92-3
• 化学式: C₁₉H₃₀N₆O₄
• 分子量: 406.485
• InChiKey: QLOKBWYFXPIIJL-KQQSKNTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.76
• 重原子数：
  29.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  175.58
• 氢给体数：
  7.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  7-氨基-4-甲基香豆素-3-乙酸N-琥珀酰亚胺酯 、 (R)-5-Guanidino-2-[(Z)-3-(4-hydroxy-phenyl)-acryloylamino]-pentanoic acid [2-(2-amino-ethoxy)-ethyl]-amide 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以78%的产率得到N-{[2-(7-amino-4-methylcoumarin-3-acetyl)amino]ethoxyethyl} N_α-cis-p-coumaroyl-D-arginine amide
  参考文献：
  名称：

  Fluorescence studies on nyctinasty using fluorescence labeled cis-p-coumaroylagmatine, a leaf-opening substance of Albizzia plants: existence of genus-specific receptor for leaf-movement factor

  摘要：

  We developed fluorescent probes (1 and 2) based on the structure of cis-p-coumaroylagmatine (3), a leaf-opening Substance of Albizzia julibrissim Durazz. These probes were effective for the leaf-opening of A. julibrissin, and specifically bind to the motor cell of this plant. Moreover, binding of the fluorescent probe was specific to the plant motor cell contained in the plants belonging to the Albizzia genus. These results showed that the binding of a probe compound with a motor cell is specific to the plant genus and suggested that the genus-specific receptor molecule Cor the leaf movement factor on a motor cell Would be involved in nyctinasty. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00376-9
• 作为产物：
  描述：

  4-羟基肉桂酸 在 dimethylthiazolyl methylmorpholine 、 三氟乙酸 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-5-Guanidino-2-[(Z)-3-(4-hydroxy-phenyl)-acryloylamino]-pentanoic acid [2-(2-amino-ethoxy)-ethyl]-amide
  参考文献：
  名称：

  Fluorescence studies on nyctinasty using fluorescence labeled cis-p-coumaroylagmatine, a leaf-opening substance of Albizzia plants: existence of genus-specific receptor for leaf-movement factor

  摘要：

  We developed fluorescent probes (1 and 2) based on the structure of cis-p-coumaroylagmatine (3), a leaf-opening Substance of Albizzia julibrissim Durazz. These probes were effective for the leaf-opening of A. julibrissin, and specifically bind to the motor cell of this plant. Moreover, binding of the fluorescent probe was specific to the plant motor cell contained in the plants belonging to the Albizzia genus. These results showed that the binding of a probe compound with a motor cell is specific to the plant genus and suggested that the genus-specific receptor molecule Cor the leaf movement factor on a motor cell Would be involved in nyctinasty. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00376-9