(5-溴-2-甲氧基苄基)-二甲胺 | 7078-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (5-溴-2-甲氧基苄基)-二甲胺
• 英文名称: (5-bromo-2-methoxybenzyl)dimethylamine
• 英文别名: 1-(5-bromo-2-methoxyphenyl)-N,N-dimethylmethylamine；1-(5-Bromo-2-methoxyphenyl)-n,n-dimethylmethanamine
• CAS: 7078-90-2
• 化学式: C₁₀H₁₄BrNO
• mdl: MFCD02640922
• 分子量: 244.131
• InChiKey: LYFFUJLINWPKAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2922299090

反应信息

• 作为反应物：
  描述：

  (5-溴-2-甲氧基苄基)-二甲胺 在 palladium diacetate 、 sodium hydroxide 、 1,3-双(二苯基膦)丙烷 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 (E)-3-[2-[2-(dimethylamino)ethoxy]-5-(3,5-dimethylphenyl)phenyl]-1-[3-[(dimethylamino)methyl]-4-methoxyphenyl]prop-2-en-1-one
  参考文献：
  名称：

  Cationic Chalcone Antibiotics. Design, Synthesis, and Mechanism of Action

  摘要：

  This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the beta-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the A-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 mu M against methicillin resistant Staphylococus aureus.

  DOI：

  10.1021/jm049424k
• 作为产物：
  描述：

  5-溴-2-甲氧基苯甲醇 在 氯化亚砜 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 (5-溴-2-甲氧基苄基)-二甲胺
  参考文献：
  名称：

  Cationic Chalcone Antibiotics. Design, Synthesis, and Mechanism of Action

  摘要：

  This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the beta-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the A-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 mu M against methicillin resistant Staphylococus aureus.

  DOI：

  10.1021/jm049424k

文献信息

• Amino-functional chalcones
  申请人：Nielsen Feldbaek Simone

  公开号：US20060052600A1

  公开（公告）日：2006-03-09

  The invention provides novel amino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, and bacteriocidal agents.

  本发明提供了新型氨基功能化的查尔酮衍生物及其类似物。本发明还揭示了将该化合物或包含其的组合物用作药物活性剂，特别是用于治疗细菌和寄生虫感染。本发明还涉及一种检测抑制细菌、寄生虫、真菌和蠕虫等的方法。本发明的查尔酮具有氨基取代基，具有增强的生物效应和改善的代谢和物理化学性质，使该化合物可用作药物物质，特别是作为抗寄生虫和杀菌剂。
• Aminoalkoxy-functional chalcones
  申请人：Nielsen Feldbaek Simon

  公开号：US20050227990A1

  公开（公告）日：2005-10-13

  The invention provides novel alkoxyaminochalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, bacteriostatic, and bacteriocidal agents.

  本发明提供了新型的烷氧基氨基查尔酮衍生物及其类似物。本发明还揭示了将该化合物或包含它们的组合物用作药物活性剂，特别是用于对抗细菌和寄生虫感染。本发明还涉及一种检测抑制作用的方法，例如对细菌、寄生虫、真菌和蠕虫的抑制作用。本发明的查尔酮带有氨基取代基，并展示出增强的生物效应和改善的代谢和物理化学性质，使得该化合物可用作药物物质，特别是作为抗寄生虫、细菌静止和杀菌剂。
• Diamino-functional chalcones
  申请人：Nielsen Feldbaek Simon

  公开号：US20060235073A1

  公开（公告）日：2006-10-19

  The invention provides novel diamino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.

  本发明提供了新型二氨基官能化查尔酮衍生物及其类似物。本发明还揭示了将这些化合物或包含它们的组合物用作药物活性剂，特别是用于对抗细菌和寄生虫感染。本发明还涉及一种检测抑制对细菌、寄生虫、真菌和蠕虫等的影响的方法。本发明的查尔酮具有氨基取代基，并表现出增强的生物效应和改善的代谢和物理化学性质，使这些化合物在药物物质中有用，特别是作为抗寄生虫和抗菌剂。
• [EN] BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF<br/>[FR] COMPOSÉ BICYCLIQUE SERVANT D'INHIBITEUR DE HPK1 ET SON UTILISATION<br/>[ZH] 作为HPK1抑制剂的双环类化合物及其应用
  申请人：JIANGSU SIMCERE PHARM CO LTD

  公开号：WO2022171034A1

  公开（公告）日：2022-08-18

  提供了式(I)所示化合物或其药学上可接受的盐、药物组合物及其制备方法，以及作为HPK1抑制剂的用途。
• [EN] AMINOALKOXY-FUNCTIONAL CHALCONES<br/>[FR] CHALCONES A FONCTION AMINOALKOXY
  申请人：——

  公开号：WO2003097574A3

  公开（公告）日：2004-02-26