2,8-二羟基-辛酸 | 66997-43-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 2,8-二羟基-辛酸
• 英文名称: 2,8-dihydroxy-octanoic acid
• 英文别名: 2.8-Dihydroxyoctansaeure；2,8-Dihydroxyoctanoic acid
• CAS: 66997-43-1
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: KZAQVJGMMMJHCD-UHFFFAOYSA-N

物化性质

• 沸点：
  379.3±27.0 °C(Predicted)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,8-二羟基-辛酸 在 chromium(VI) oxide 作用下， 生成 7-hydroxyheptanal
  参考文献：
  名称：

  Three-electron oxidations. 13. Intramolecular cooxidation of 2,7-dihydroxyheptanoic acid. Structure of the transition state in the chromium(VI) oxidation of alcohols

  摘要：

  DOI：

  10.1021/ja00477a035
• 作为产物：
  描述：

  6-氯-1-己醇 、 氰化钾 生成 2,8-二羟基-辛酸
  参考文献：
  名称：

  Three-electron oxidations. 13. Intramolecular cooxidation of 2,7-dihydroxyheptanoic acid. Structure of the transition state in the chromium(VI) oxidation of alcohols

  摘要：

  DOI：

  10.1021/ja00477a035

文献信息

• Lipoic acid derivatives and their use in treatment of disease
  申请人：——

  公开号：US20020107234A1

  公开（公告）日：2002-08-08

  This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.

  本发明涉及一种新型治疗剂的鉴定，该治疗剂选择性地针对并杀死肿瘤细胞和某些其他类型的疾病细胞，并且涉及包含脂酰辅酶A衍生物的组合物，该衍生物特异性地破坏这些细胞中的丙酮酸脱氢酶复合物。本发明还提供了使用治疗有效量的脂酰辅酶A衍生物治疗癌症和其他疾病的方法。本发明中描述的脂酰辅酶A衍生物具有广泛的预防和治疗应用。
• Process for preparing hydroxycarboxylic acids
  申请人：UNILEVER PLC

  公开号：EP0711746A1

  公开（公告）日：1996-05-15

  A new synthesis of ω-hydroxy acids, which employs commercially available starting materials and lowers the cost of production. The process involves coupling a fatty acyl group by enamine chemistry, followed by a ring expansion and selective reduction of ketoacid.

  一种新的ω-羟基酸合成法，它采用了市场上可买到的起始原料，并降低了生产成本。该工艺包括用烯胺化学方法偶联脂肪酰基，然后进行扩环和选择性还原酮酸。
• Plasticizer for biodegradable resin
  申请人：KAO CORPORATION

  公开号：EP1728818A1

  公开（公告）日：2006-12-06

  The present invention relates to a plasticizer for biodegradable resin, which contains a compound represented by the following formula (1): wherein at least one of R1, R2 and R3 is an acyl group derived from a carboxylic acid selected from an aliphatic hydroxycarboxylic acid and an acetylated aliphatic hydroxycarboxylic acid, and the remainder(s) is an acetyl group, a biodegradable resin composition containing biodegradable resin and the plasticizer.

  本发明涉及一种用于生物降解树脂的增塑剂，它含有下式（1）所代表的化合物： 其中 R1、R2 和 R3 中至少有一个是由选自脂肪族羟基羧酸和乙酰化脂肪族羟基羧酸的羧酸衍生的酰基，其余的是乙酰基，一种含有可生物降解树脂和该增塑剂的可生物降解树脂组合物。
• Dibenzyl lipoic acid derivatives and their use in treatment of disease
  申请人：The Research Foundation Of The State University Of New York

  公开号：EP2145883A1

  公开（公告）日：2010-01-20

  The invention provides a method of inhibiting proliferation of diseased cells by contacting the diseased cells with an effective amount of a reagent that inhibits PDC specifically in said diseased cells.

  本发明提供了一种抑制病变细胞增殖的方法，方法是将病变细胞与有效量的试剂接触，该试剂可特异性地抑制病变细胞中的 PDC。
• Electrostatic ink compositions and scratch-off structures
  申请人：HP Indigo B.V.

  公开号：US11112717B2

  公开（公告）日：2021-09-07

  Disclosed herein is an electrostatic ink composition comprising a component selected from a fatty acid ester having a plurality of hydroxyl substituents and a fatty acid amide having a plurality of hydroxyl substituents. Also described herein are scratch-off structures and methods for producing them.

  本文公开了一种静电油墨组合物，其成分选自具有多个羟基取代基的脂肪酸酯和具有多个羟基取代基的脂肪酸酰胺。本文还描述了刮擦结构及其生产方法。