1-[4-Methoxy-3,5-bis(phenylmethoxy)phenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol | 180900-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[4-Methoxy-3,5-bis(phenylmethoxy)phenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol
• CAS: 180900-48-5
• 化学式: C₃₄H₃₈O₈
• 分子量: 574.671
• InChiKey: OGOCKENUZGNXRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  95.8
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-[4-Methoxy-3,5-bis(phenylmethoxy)phenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol 在 palladium on activated charcoal 吡啶 、 氢气 、 potassium carbonate 、 三氟乙酸 作用下， 以 乙醇 、 氯仿 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 25.0~80.0 ℃ 、101.33 kPa 条件下， 反应 24.03h， 生成
  参考文献：
  名称：

  Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

  摘要：

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.

  DOI：

  10.1016/0223-5234(96)89161-6
• 作为产物：
  描述：

  Ethyl 3-[4-methoxy-3,5-bis(phenylmethoxy)phenyl]-3-oxopropanoate 在 sodium hydroxide 、 sodium tetrahydroborate 、 sodium hydride 作用下， 以 乙醇 为溶剂， 反应 14.83h， 生成 1-[4-Methoxy-3,5-bis(phenylmethoxy)phenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol
  参考文献：
  名称：

  Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

  摘要：

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.

  DOI：

  10.1016/0223-5234(96)89161-6