2-(1H-2-indenyl)-2-methyl-1,3-diphenyl-1-propanone | 1296863-27-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(1H-2-indenyl)-2-methyl-1,3-diphenyl-1-propanone
• 英文别名: 2-(1H-inden-2-yl)-2-methyl-1,3-diphenylpropan-1-one
• CAS: 1296863-27-8
• 化学式: C₂₅H₂₂O
• 分子量: 338.449
• InChiKey: QYVKVZKNRBVJMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(1H-2-indenyl)-2-methyl-1,3-diphenyl-1-propanone 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 1.0h， 生成 2-(1H-2-indenyl)-2-methyl-1,3-diphenyl-1-propanol
  参考文献：
  名称：

  Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds

  摘要：

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.073
• 作为产物：
  描述：

  indan-2-one ethylene ketal 在 potassium tert-butylate 、 四氯化锡 作用下， 以 乙醚 、 二氯甲烷 、 叔丁醇 为溶剂， 反应 1.0h， 生成 2-(1H-2-indenyl)-2-methyl-1,3-diphenyl-1-propanone
  参考文献：
  名称：

  Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds

  摘要：

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.073

文献信息

• Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds
  作者：James W. Barlow、Aengus P. McHugh、Orla Woods、John J. Walsh

  DOI：10.1016/j.ejmech.2011.01.073

  日期：2011.5

  In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C-C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1,2,3,4-tetrahydro-1-naphthalenol 12 exhibited most promising activity both in vitro and in vivo. (C) 2011 Elsevier Masson SAS. All rights reserved.