2-methyl-1-[(1S)-1-phenylethyl]-1H-imidazole | 99530-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-1-[(1S)-1-phenylethyl]-1H-imidazole
• 英文别名: Efetozole, (S)-；2-methyl-1-[(1S)-1-phenylethyl]imidazole
• CAS: 99530-99-1
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: CILDGVODBJAMGO-JTQLQIEISA-N

物化性质

• 沸点：
  303.2±11.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-[(1S)-phenylethyl]ethane-1,2-diamine 在 potassium permanganate 、 苄基三乙基溴化铵 、 溶剂黄146 作用下， 以 水 、 乙腈 、 苯 为溶剂， 反应 2.0h， 生成 2-methyl-1-[(1S)-1-phenylethyl]-1H-imidazole
  参考文献：
  名称：

  New chiral imidazolinic derivatives

  摘要：

  Novel C-2 substituted 4,5-dihydroimidazoles and imidazoles bearing an N-linked stereogenic group were rapidly prepared from a chiral primary amine. Quaternization of these derivatives resulted in a range of scalemic room temperature ionic liquids. The ability of the imidazolium species to act as reaction medium and/or phase transfer catalyst was also assessed. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.01.014

文献信息

• New chiral imidazolinic derivatives
  作者：Yves Génisson、Nancy Lauth-de Viguerie、Chantal André、Michel Baltas、Liliane Gorrichon

  DOI：10.1016/j.tetasy.2005.01.014

  日期：2005.3

  Novel C-2 substituted 4,5-dihydroimidazoles and imidazoles bearing an N-linked stereogenic group were rapidly prepared from a chiral primary amine. Quaternization of these derivatives resulted in a range of scalemic room temperature ionic liquids. The ability of the imidazolium species to act as reaction medium and/or phase transfer catalyst was also assessed. (C) 2005 Elsevier Ltd. All rights reserved.