4-imidazo[1,2-a]pyridin-2-yl-5-methyl-2-propan-2-ylphenol | 205655-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-imidazo[1,2-a]pyridin-2-yl-5-methyl-2-propan-2-ylphenol
• CAS: 205655-13-6
• 化学式: C₁₇H₁₈N₂O
• 分子量: 266.343
• InChiKey: GCVPHNZRYSKFFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.14
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  37.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-二乙氨基氯乙烷盐酸盐 、 4-imidazo[1,2-a]pyridin-2-yl-5-methyl-2-propan-2-ylphenol 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以77%的产率得到
  参考文献：
  名称：

  Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria

  摘要：

  Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10013-x
• 作为产物：
  描述：

  2-氨基吡啶 、 4-hydroxy-3-isopropyl-6-methylphenacyl bromide 以 氯仿 为溶剂， 反应 8.0h， 以80%的产率得到4-imidazo[1,2-a]pyridin-2-yl-5-methyl-2-propan-2-ylphenol
  参考文献：
  名称：

  Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria

  摘要：

  Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10013-x