N-(2-azidoethyl)-2-(1,4,7,10-tetraazacyclododecan-1-yl)acetamide | 1365769-19-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-azidoethyl)-2-(1,4,7,10-tetraazacyclododecan-1-yl)acetamide
• CAS: 1365769-19-2
• 化学式: C₁₂H₂₆N₈O
• 分子量: 298.391
• InChiKey: OXIYNNNPNODECP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  117.19
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-(2-azidoethyl)-2-(1,4,7,10-tetraazacyclododecan-1-yl)acetamide 在 sodium carbonate 、 三氟乙酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 38.0h， 生成 2,2',2''-(10-(2-(2-azidoethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
  参考文献：
  名称：

  Luminescent Lanthanide Complexes with Analyte-Triggered Antenna Formation

  摘要：

  A new strategy for accessing analyte-responsive luminescent probes is presented. The lanthanide luminescence of Eu and Tb centers is switched on by the analyte-triggered formation of a sensitizing antenna from a nonsensitizing caged precursor. As the cage can be freely varied, an array of probes for different analytes (pd(0/2+), H2O2, F-, beta-galactosidase) can be created from the same core structure. The probe design affords nanomolar to micromolar detection limits, provides the capability to detect two analytes in parallel, and can be utilized to monitor enzymatic activity in live cells.

  DOI：

  10.1021/ja3004045
• 作为产物：
  描述：

  N-chloroacetyl-2-azidoethylamine 、 轮环藤宁 以 氯仿 为溶剂， 反应 18.0h， 以82%的产率得到N-(2-azidoethyl)-2-(1,4,7,10-tetraazacyclododecan-1-yl)acetamide
  参考文献：
  名称：

  Luminescent Lanthanide Complexes with Analyte-Triggered Antenna Formation

  摘要：

  A new strategy for accessing analyte-responsive luminescent probes is presented. The lanthanide luminescence of Eu and Tb centers is switched on by the analyte-triggered formation of a sensitizing antenna from a nonsensitizing caged precursor. As the cage can be freely varied, an array of probes for different analytes (pd(0/2+), H2O2, F-, beta-galactosidase) can be created from the same core structure. The probe design affords nanomolar to micromolar detection limits, provides the capability to detect two analytes in parallel, and can be utilized to monitor enzymatic activity in live cells.

  DOI：

  10.1021/ja3004045