(联苯-4-羰基)-氨基]-乙酸 | 75446-59-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (联苯-4-羰基)-氨基]-乙酸
• 英文名称: N-([1,1'-biphenyl]-4-ylcarbonyl)glycine
• 英文别名: ([1,1'-biphenyl]-4-carbonyl)glycine；4-phenylhippuric acid；p-Phenyl-hippursaeure；N-(biphenyl-4-carbonyl)-glycine；[(biphenyl-4-carbonyl)-amino]-acetic acid；2-[(4-Phenylbenzoyl)amino]acetic acid；N-(Biphenyl-4-carbonyl)-glycin
• CAS: 75446-59-2
• 化学式: C₁₅H₁₃NO₃
• mdl: MFCD00045900
• 分子量: 255.273
• InChiKey: MYJXSDFBYVYUCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.066
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  (联苯-4-羰基)-氨基]-乙酸 在 乙酸酐 作用下， 生成 4-benzylidene-2-biphenyl-4-yl-4H-oxazol-5-one
  参考文献：
  名称：

  145.与脂肪醛的锥形反应，使用2-苯基恶唑-5-酮代替马尿酸

  摘要：

  DOI：

  10.1039/jr9590000729
• 作为产物：
  描述：

  4-苯基苯甲酸 在 氯化亚砜 、 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (联苯-4-羰基)-氨基]-乙酸
  参考文献：
  名称：

  Synthesis, Biological Evaluation and In Silico Investigation of Novel Functionalized Imidazole-Based KDM6 Inhibitors

  摘要：

  DOI：

  10.21608/ejchem.2020.38209.2790

文献信息

• 7-oxabicycloheptane .alpha.-substituted ketone prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04638012A1

  公开（公告）日：1987-01-20

  7-Oxabicycloheptane .alpha.-substituted ketone prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; X is halogen, alkanoyloxy or hydroxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, amino, alkylamino, or arylamino. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了具有结构式的7-氧杂双环庚烷α-取代酮前列腺素类似物##STR1##其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2--CH.sub.2--；n为1至5；X为卤素、烷酰氧基或羟基；p为1至4；R.sup.1为H或较低烷基；q为1至12；R.sup.2为H或较低烷基；R.sup.3为H、较低烷基、较低烯基、较低炔基、芳基、芳基烷基、较低烷氧基、芳氧基、氨基、烷基氨基或芳基氨基。这些化合物是心血管药物，例如，在治疗血栓性疾病方面很有用。
• Bicycloheptane substituted diamide and its congener prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04734424A1

  公开（公告）日：1988-03-29

  Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了具有结构式##STR1##的双环庚烷取代酰胺前列腺素类似物，其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；Q为--CH.dbd.CH--，--CH.sub.2 --，##STR2##或单键；R为CO.sub.2 H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2 OH，##STR3##其中R.sup.4和R.sup.5相同或不同，为H，低烷基，羟基，低烷氧基或芳基，R.sup.4和R.sup.5中至少有一个不是羟基和低烷氧基；p为1至4；R.sup.1为H或低烷基；q为1至12；R.sup.2为H或低烷基；R.sup.3为H，低烷基，低烯基，低炔基，芳基，芳基烷基，低烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基，芳基氨基，芳基烷基氨基，低烷基-S-，芳基-S-，芳基烷基-S-，##STR4##（其中n'为0，1或2），烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基。这些化合物是心血管药物，例如，在治疗血栓性疾病中有用。
• 7-oxabicycloheptane substituted diamide and its congener prostaglandin
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04663336A1

  公开（公告）日：1987-05-05

  7-Oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了具有结构式##STR1##的7-氧代双环庚烷取代酰胺前列腺素类似物，其中m为0至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；Q为--CH.dbd.CH--，--CH.sub.2 --，##STR2##或单键；R为CO.sub.2 H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2 OH，##STR3##其中R.sup.4和R.sup.5相同或不同，为H，低烷基，羟基，低烷氧基或芳基，R.sup.4和R.sup.5中至少有一个不是羟基和低烷氧基；p为1至4；R.sup.1为H或低烷基；q为1至12；R.sup.2为H或低烷基；R.sup.3为H，低烷基，低烯基，低炔基，芳基，芳基烷基，低烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基，芳基氨基，芳基烷基氨基，##STR4##（其中n'为0，1或2），烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基。这些化合物是心血管药物，例如，在治疗血栓性疾病方面有用。
• 7-thiabicycloheptane substituted diamide and its congener prostaglandin
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04735962A1

  公开（公告）日：1988-04-05

  7-Thiabicycloheptane substituted diamide and congener prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 1 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR2## wherein R.sup.3 and R.sup.4 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.3 and R.sup.4 being other than hydroxy and lower alkoxy; p is 1 to 4; Z is ##STR3## q is 1 to 12; R.sup.1 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了7-硫代双环庚烷取代二酰胺和同系物前列腺素类似物，其具有结构式##STR1##其中m为1至4；A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；R为CO.sub.2 H，CO.sub.2烷基，CO.sub.2碱金属，CO.sub.2多羟胺盐，--CH.sub.2 OH，##STR2##其中R.sup.3和R.sup.4相同或不同，为H，低烷基，羟基，低烷氧基或芳基，R.sup.3和R.sup.4中至少有一个不是羟基和低烷氧基；p为1至4；Z为##STR3##q为1至12；R.sup.1为H或低烷基；R.sup.3为H，低烷基，低烯基，低炔基，芳基，芳基烷基，低烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基，芳基氨基，芳基烷基氨基，##STR4##（其中n'为0、1或2），烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基。这些化合物是心血管药物，例如，在治疗血栓性疾病中有用。
• 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04734426A1

  公开（公告）日：1988-03-29

  5,6-Epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt or ##STR2## q is 1 to 12; and R.sup.1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

  提供了具有结构式的5,6-环氧-7-氧代双胺前列腺素类似物的结构式，其中A为--CH.dbd.CH--或--CH.sub.2 --CH.sub.2 --；n为1至5；R为CO.sub.2 H，CO.sub.2 烷基，CO.sub.2 碱金属，CO.sub.2 多羟胺盐或q为1至12；R.sup.1为H，低烷基，低烯烃基，低炔基，芳基，芳基烷基，低烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基芳基氨基，芳基烷基氨基，(其中n'为0、1或2)，烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基。这些化合物是心血管药物，例如，可用于治疗血栓性疾病。