1-(2-methyl-thiazol-4-yl)-ethanone oxime | 23002-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-methyl-thiazol-4-yl)-ethanone oxime
• 英文别名: 2-Methyl-4-acetylthiazol-oxim；Ethanone, 1-(2-methyl-4-thiazolyl)-, oxime；N-[1-(2-methyl-1,3-thiazol-4-yl)ethylidene]hydroxylamine
• CAS: 23002-77-9
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: FWROCYSXRUFAEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-methyl-thiazol-4-yl)-ethanone oxime 在 五氯化磷 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以73%的产率得到N-(thiazol-4-yl)acetamide
  参考文献：
  名称：

  Thiazolo[4,5-d]thiazole—a new domain for potential optoelectronic application

  摘要：

  A novel heterocyclic moiety based on thiazolo[4.5-d]thiazole was prepared via a six-step synthesis from butane-2,3-dione. This thiazolothiazole compound was further derivatized to afford either neutral conjugated condensation products or analogous N-alkyl salts. The obtained derivatives represent dipolar structures expressed as A-pi-D (push-pull compounds) as well as quadrupolar D-pi-A-pi-D structures. Both types of compound show intramolecular charge transfer and therefore could be suitable for nonlinear optical applications. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.110
• 作为产物：
  描述：

  1-溴丁烷-2,3-二酮 3-肟 、 硫代乙酰胺 以 苯 为溶剂， 反应 2.0h， 生成 1-(2-methyl-thiazol-4-yl)-ethanone oxime
  参考文献：
  名称：

  Beckmannsche Umlagerungen in der Thiazol-Reihe

  摘要：

  DOI：

  10.1007/bf00900881

文献信息

• Beckmannsche Umlagerungen in der Thiazol-Reihe
  作者：András Benkő、Ioan Rotaru

  DOI：10.1007/bf00900881

  日期：1975.7
• Thiazolo[4,5-d]thiazole—a new domain for potential optoelectronic application
  作者：Peter Zahradník、Peter Magdolen、Pavol Zahradník

  DOI：10.1016/j.tetlet.2010.08.110

  日期：2010.11

  A novel heterocyclic moiety based on thiazolo[4.5-d]thiazole was prepared via a six-step synthesis from butane-2,3-dione. This thiazolothiazole compound was further derivatized to afford either neutral conjugated condensation products or analogous N-alkyl salts. The obtained derivatives represent dipolar structures expressed as A-pi-D (push-pull compounds) as well as quadrupolar D-pi-A-pi-D structures. Both types of compound show intramolecular charge transfer and therefore could be suitable for nonlinear optical applications. (C) 2010 Elsevier Ltd. All rights reserved.