2-Heptanoylcyclohexanone | 122059-99-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Heptanoylcyclohexanone
• 英文别名: Cyclohexanone, 2-(1-oxoheptyl)-；2-heptanoylcyclohexan-1-one
• CAS: 122059-99-8
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: GVWBMACEITYPFO-UHFFFAOYSA-N

物化性质

• 沸点：
  146 °C(Press: 6 Torr)
• 密度：
  0.970±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Heptanoylcyclohexanone 在 氢氧化钾 作用下， 反应 4.0h， 以80%的产率得到7-oxotridecanoic acid
  参考文献：
  名称：

  Synthesis of the antifungal agent norneoenactin A

  摘要：

  The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropriate vinyl ketone 4. Biological activity of the two enantiomers of norneoenactin A ((S)-1 and (R)-1) against Escherichia coli and several fungi has been investigated.

  DOI：

  10.1021/jo00074a038
• 作为产物：
  描述：

  1-吗啉基-1-环己烯 、 庚酰氯 在 盐酸 、 三乙胺 作用下， 生成 2-Heptanoylcyclohexanone
  参考文献：
  名称：

  Synthesis of the antifungal agent norneoenactin A

  摘要：

  The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropriate vinyl ketone 4. Biological activity of the two enantiomers of norneoenactin A ((S)-1 and (R)-1) against Escherichia coli and several fungi has been investigated.

  DOI：

  10.1021/jo00074a038

文献信息

• PRATAP, G.;SHANTHA, K. L.;BHASKAR, RAO V. S., FETT WISS. TECHNOL., 91,(1989) N, C. 68-72
  作者：PRATAP, G.、SHANTHA, K. L.、BHASKAR, RAO V. S.

  DOI：——

  日期：——
• Synthesis of the antifungal agent norneoenactin A
  作者：Ihab S. Darwish、Chetna Patel、Marvin J. Miller

  DOI：10.1021/jo00074a038

  日期：1993.10

  The first total and unequivocal syntheses of (R)- and (S)-norneoenactin A (1), an analog of the antifungal antibiotic neoenactin A, are described. The key step of each synthesis was the Michael addition of a serinehydroxamate (5 or 8) to the appropriate vinyl ketone 4. Biological activity of the two enantiomers of norneoenactin A ((S)-1 and (R)-1) against Escherichia coli and several fungi has been investigated.