4,8-Dioxaspiro[2.5]oct-1-ene, 1,1'-(1,4-butanediyl)bis[6,6-dimethyl- | 122762-84-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,8-Dioxaspiro[2.5]oct-1-ene, 1,1'-(1,4-butanediyl)bis[6,6-dimethyl-
• 英文别名: 2-[4-(6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-en-2-yl)butyl]-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene
• CAS: 122762-84-9
• 化学式: C₂₀H₃₀O₄
• 分子量: 334.456
• InChiKey: TZFDQOWVEHRPMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  430.6±45.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,8-Dioxaspiro[2.5]oct-1-ene, 1,1'-(1,4-butanediyl)bis[6,6-dimethyl- 在 甲醇 、 silver trifluoromethanesulfonate 、 三乙胺 作用下， 反应 8.5h， 以93%的产率得到
  参考文献：
  名称：

  Macrocarbocycle Synthesis by Copper- and Silver-Mediated Cyclization of Tethered Cyclopropenone Acetals. Electronic Tuning of Metal Vinylcarbene Complex into Vinylmetallic Species

  摘要：

  [GRAPHICS]Synthesis of n-membered medium and macrocarbocycles through intramolecular sp(2)-sp(2) C-C bond formation was achieved with the aid of CuOTf or AgOTf by intramolecular coupling reaction of cyclopropenone acetals tethered by a methylene chain of (n - 4) carbon atoms, The reaction has proved to be useful for the synthesis of large carbocycles (n > 13) in yields as high as 78%, and most notably also for an eight-membered carbocycle in 88% yield.

  DOI：

  10.1021/ol990053p
• 作为产物：
  描述：

  1-氯-6,6-二甲基-4,8-二氧杂螺[2.5]辛烷 在 六甲基磷酰三胺 、 正丁基锂 、 氯化铵 、 sodium amide 作用下， 反应 6.5h， 生成 4,8-Dioxaspiro[2.5]oct-1-ene, 1,1'-(1,4-butanediyl)bis[6,6-dimethyl-
  参考文献：
  名称：

  环丙烯酮及其缩醛的一般合成

  摘要：

  金属化的环丙烯酮乙缩醛5与各种亲电子试剂反应，包括烷基卤，羰基化合物，乙烯基碘，乙烯基三氟甲磺酸酯和芳基碘，以高收率得到取代的环丙烯酮乙缩醛。缩醛在酸性条件下的水解得到相应的环丙烯酮。该反应序列已经实现了抗生素青霉素（1）的有效合成。

  DOI：

  10.1016/s0040-4020(01)88873-6

文献信息

• Regio- and diastereo-controlled double cycloaddition to [60] fullerene: one-step synthesis of Cs and C2 chiral organofullerenes with new tris-annulating reagents
  作者：Eiichi Nakamura、Hiroyuki Isobe、Hidetoshi Tokuyama、Masaya Sawamura

  DOI：10.1039/cc9960001747

  日期：——

  Double cycloaddition of new tris-annulation reagents to [60]fullerene creates a tricyclic system constructed on the [60]fullerene sphere, providing Cs symmetric and C2 chiral non-racemic organofullerenes.

  新型三重环加成试剂对 [60]富勒烯进行双环加成，形成了构建在 [60]富勒烯球体上的三环系统，提供了Cs对称和C2手性的非消旋有机富勒烯。
• Synthetic and Computational Studies on Symmetry-Defined Double Cycloaddition of a New Tris-Annulating Reagent to C₆₀
  作者：Hiroyuki Isobe、Hidetoshi Tokuyama、Masaya Sawamura、Eiichi Nakamura

  DOI：10.1021/jo970685u

  日期：1997.7.1

  For the purpose of doubly functionalizing fullerenes, new tris-annulating reagents 2(n) have been developed. The reagents carry, in one molecule, two cyclopropenone acetals which are connected with an n-carbon methylene tether. Upon thermolysis of 2(n) in the presence of C-60, the reagent undergoes [3 + 2] cycloaddition reaction twice in a regio- and stereoselective manner to give C-s and C-2 organofullerenes bearing two cyclopentenone acetals. The selectivity varies as the function of the tether structure. The experiments have shown that, in each series of different tether lengths, one can obtain one or two diastereomeric double adducts out of several structural possibilities. The selectivity of the reaction did not conform to the prediction made on the basis of previous knowledge on intermolecular double additions but was found to be correlated to the conformational strain of the tether moiety, which can be estimated by a newly developed ''double differential protocol''. Systematic studies on the reliability of various computational methods for organofullerenes indicated that certain molecular orbital and molecular mechanics calculations give very reliable structural data while certain others do not.
• Applications of metalated cyclopropenone ketals in a general synthesis of cyclopropenones. An efficient synthesis of the antibiotic penitricin
  作者：Masahiko Isaka、Satoshi Matsuzawa、Shigeru Yamago、Satoshi Ejiri、Yoshimitsu Miyachi、Eiichi Nakamura

  DOI：10.1021/jo00281a001

  日期：1989.9