3,7,3'-trimethoxy-4',5'-dihydroxyflavone | 223902-81-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,7,3'-trimethoxy-4',5'-dihydroxyflavone
• 英文别名: 2-(3,4-dihydroxy-5-methoxy-phenyl)-3,7-dimethoxy-chromen-4-one；2-(3,4-Dihydroxy-5-methoxy-phenyl)-3,7-dimethoxy-chromen-4-on；4',5'-Dihydroxy-3,7,3'-trimethoxyflavone；2-(3,4-dihydroxy-5-methoxyphenyl)-3,7-dimethoxychromen-4-one
• CAS: 223902-81-6
• 化学式: C₁₈H₁₆O₇
• 分子量: 344.321
• InChiKey: CXNYWXODOUUFAW-UHFFFAOYSA-N

物化性质

• 熔点：
  200 °C(Solv: ethanol (64-17-5))
• 沸点：
  595.5±50.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  94.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,7,3'-trimethoxy-4',5'-dihydroxyflavone 在 氢碘酸 、 乙酸酐 作用下， 生成 洋槐黄素
  参考文献：
  名称：

  Nuclear oxidation in flavones and related compounds

  摘要：

  DOI：

  10.1007/bf03171364
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 双氧水 作用下， 生成 3,7,3'-trimethoxy-4',5'-dihydroxyflavone
  参考文献：
  名称：

  Nuclear oxidation in flavones and related compounds

  摘要：

  DOI：

  10.1007/bf03171364

文献信息

• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。
• Rubber composition and tire with rubber containing flavone
  申请人：The Goodyear Tire & Rubber Company

  公开号：EP2730431A1

  公开（公告）日：2014-05-14

  A rubber composition comprising a diene based elastomer and an adhesion promoter derived from a flavone, a methylene donor and a methylene acceptor is disclosed. The rubber composition is essentially free of cobalt. Also, a pneumatic tire comprising such a rubber composition is disclosed.

  本发明公开了一种橡胶组合物，该组合物包含一种二烯基弹性体和一种由黄酮、亚甲基供体和亚甲基受体衍生的附着力促进剂。该橡胶组合物基本上不含钴。此外，还公开了一种包含这种橡胶组合物的充气轮胎。
• Methods For Treating Wounds
  申请人：Kimberly-Clark Worldwide, Inc.

  公开号：US20030125264A1

  公开（公告）日：2003-07-03

  Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissues and cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.

  本发明提供了利用有效量的一种或多种黄酮、黄酮醇、黄烷酮、异黄烷酮和异黄酮来增加各种组织和细胞系的细胞增殖的药物组合物及其使用方法。举例来说，本发明的组合物和方法可用于增加成纤维细胞的增殖，特别是用于治疗伤口和强化皮肤。
• US6872771B1
  申请人：——

  公开号：US6872771B1

  公开（公告）日：2005-03-29
• [EN] COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID<br/>[FR] COMPOSITIONS ET METHODES D'AUGMENTATION DE LA PROLIFERATION CELLULAIRE CONTENANT UN FLAVONOIDE
  申请人：KIMBERLY CLARK CO

  公开号：WO2003057210A1

  公开（公告）日：2003-07-17

  Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissuesand cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.