4'-methoxy-2-aminopropiophenone hydrochloride | 42416-75-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4'-methoxy-2-aminopropiophenone hydrochloride
• 英文别名: (+/-)-4-Methoxycathinone hydrochloride；2-amino-4'-methoxypropiophenone hydrochloride；2-amino-1-(4-methoxy-phenyl)-propan-1-one; hydrochloride；2-Amino-1-(4-methoxy-phenyl)-propan-1-on; Hydrochlorid；[1-(4-methoxyphenyl)-1-oxopropan-2-yl]azanium;chloride
• CAS: 42416-75-1
• 化学式: C₁₀H₁₃NO₂*ClH
• 分子量: 215.68
• InChiKey: IQSQGMBCVSMHSG-UHFFFAOYSA-N

物化性质

• 熔点：
  226 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.65
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  4'-methoxy-2-aminopropiophenone hydrochloride 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成 2-amino-1-(4-methoxyphenyl)-1-propanol
  参考文献：
  名称：

  MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the β-position

  摘要：

  Twenty-nine arylisopropylamines, substituted at the beta-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-13 inhibiting activity, which was absent in the hydroxy, methoxy, and beta-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the aryl-alkylamine scaffold. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.05.033
• 作为产物：
  描述：

  (RS)-2-三氟乙酰氨基-1-(4-甲氧基苯基)-1-丙酮 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 4'-methoxy-2-aminopropiophenone hydrochloride
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064

文献信息

• Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
  申请人：Neurocrine Biosciences, Inc.

  公开号：US06346534B1

  公开（公告）日：2002-02-12

  GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar, B, R1, R2, R3a, R3b, R4, R5, R6 and m are as defined herein.

  GnRH受体拮抗剂已被披露，可用于治疗男性和女性的各种与性激素相关的疾病。该发明的化合物具有以下结构：包括立体异构体、前药和其药用盐，其中Ar、B、R1、R2、R3a、R3b、R4、R5、R6和m的定义如本文所述。
• Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0077983A1

  公开（公告）日：1983-05-04

  New triazine derivatives represented by the formula: wherein R1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo; R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl; and Z is a group selected from and pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical compositions comprising the same.

  由以下式子表示的新型三嗪衍生物 其中 R1 是芳基、吡啶基、噻吩基、1,2,3,4-四氢喹喔啉基或 1,3,4,5-四氢-2H-1-苯并氮杂卓基，可选择被低级烷基、低级烷氧基、卤素、硝基或氧代取代； R2 是氢、低级烷基或被低级烷基或芳基（低级）烷基取代的氨基甲酰基；以及 Z 是选自以下的基团 及其药学上可接受的盐、制备工艺和包含这些物质的药物组合物。
• Tiffeneau; Levy; Ditz, Bulletin de la Societe Chimique de France, 1935, vol. <5> 2, p. 1855,1862
  作者：Tiffeneau、Levy、Ditz

  DOI：——

  日期：——
• IMIDAZO- AND PYRROLO[1,2-A]PYRIMID-4-ONES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS
  申请人：Neurocrine Biosciences, Inc.

  公开号：EP1185530A1

  公开（公告）日：2002-03-13
• US4616014A
  申请人：——

  公开号：US4616014A

  公开（公告）日：1986-10-07