4-methoxy-N¹,N¹-dimethyl-m-phenylenediamine | 192819-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxy-N¹,N¹-dimethyl-m-phenylenediamine
• 英文别名: 4-Methoxy-N¹,N¹-dimethyl-m-phenylendiamin；2-Amino-4-dimethylamino-anisol；2-Amino-4-dimethylamino-phenol-methylaether；4-methoxy-N1,N1-dimethylbenzene-1,3-diamine；4-methoxy-1-N,1-N-dimethylbenzene-1,3-diamine
• CAS: 192819-41-3
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: KSJMQUBTZAZILT-UHFFFAOYSA-N

物化性质

• 沸点：
  295.0±25.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-二甲氧基苯磺酰氯 、 4-methoxy-N¹,N¹-dimethyl-m-phenylenediamine 在 吡啶 作用下， 生成 N-(5-(dimethylamino)-2-methoxyphenyl)-3,4-dimethoxybenzenesulfonamide
  参考文献：
  名称：

  N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

  摘要：

  A series of dual OX(1)R/OX(2)R orexin antagonists was prepared based on a N-glycine-sulfonamide core. SAR studies of a screening hit led to compounds with low nanomolar affinity for both receptors and good oral bioavailability. One of these compounds, 47, has demonstrated in vivo activity in rats following oral administration. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.079
• 作为产物：
  描述：

  (4-甲氧基苯基)-二甲胺 在 盐酸 、 硫酸 、 硝酸 、 铁粉 作用下， 生成 4-methoxy-N¹,N¹-dimethyl-m-phenylenediamine
  参考文献：
  名称：

  DE234307

  摘要：

  公开号：

文献信息

• 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders
  申请人：Garcia-Echeverria Carlos

  公开号：US20080132504A1

  公开（公告）日：2008-06-05

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，它们的药用价值以及包含它们的药物组合物。
• PYRIMIDINE DERIVATIVES
  申请人：Garcia-Echeverria Carlos

  公开号：US20110201606A1

  公开（公告）日：2011-08-18

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，其用作药物和含有它们的药物组合物。
• 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS
  申请人：Garcia-Echeverria Carlos

  公开号：US20110098280A1

  公开（公告）日：2011-04-28

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  I类新型嘧啶衍生物的制备方法，以及它们作为药物和药物组合物的用途。
• SUBSTITUTED PYRROLOPYRIMIDINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150133426A1

  公开（公告）日：2015-05-14

  The present invention relates to substituted pyrrolopyrimidine compounds general formula I: in which A, X, R 1 , R 2 , m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及替代吡咯吡嘧啶化合物通式I：其中A、X、R1、R2、m和n如本文所述和定义的那样，以及制备所述化合物的方法，用于制备所述化合物的中间体化合物，包含所述化合物的制药组合物和组合物，以及用于制造治疗或预防疾病的制药组合物的使用，特别是治疗或预防增殖过度和/或血管生成障碍的疾病，作为唯一的治疗剂或与其他活性成分组合使用。
• 4-SUBSTITUED COUMARIN DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF
  申请人：Guizhou Bailing Group Pharmaceutical Co., Ltd.

  公开号：EP3354648A1

  公开（公告）日：2018-08-01

  The present Invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The Invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The Invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the Invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells.

  本发明涉及化学医药领域，尤其涉及4-取代香豆素衍生物及其制备方法和应用。本发明提供了结构式如式 I 所示的 4-取代香豆素衍生物。本发明还提供了上述 4-取代香豆素衍生物的制备方法和应用。本发明提供的化合物具有较强的抗肿瘤活性，对多种肿瘤细胞株的IC50在0.01-5 nM之间，同时在抑制微管聚合方面表现较好，具有多样化的生物活性和低毒性，为对药物敏感和耐药的肿瘤细胞提供了新的选择。