7,11-epoxymegastigma-5(6)-en-9-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: 7,11-epoxymegastigma-5(6)-en-9-ol
• 英文别名: (2S)-1-[(1S)-7,7-dimethyl-3,4,5,6-tetrahydro-1H-2-benzofuran-1-yl]propan-2-ol
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: HVXDBUSLBFIKCT-ONGXEEELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7,11-epoxymegastigma-5(6)-en-9-ol 在 氢氧化钾 、 Pseudomonas cepacia lipase PS 作用下， 以 甲醇 为溶剂， 生成 7,11-epoxymegastigma-5(6)-en-9-ol
  参考文献：
  名称：

  Synthesis and olfactory evaluation of the enantiomerically enriched forms of 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols isomers, identified in Passiflora edulis

  摘要：

  A study on the synthesis of the isomers of the natural C-13 norterpenoids derivatives 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols is reported. The latter compounds were prepared from readily available racemic alpha-ionone and then resolved by mean of lipase-mediated acetylation. The obtained enantiomerically forms were evaluated for their odour properties. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.02.021
• 作为产物：
  描述：

  γ-紫罗兰酮 在 sodium tetrahydroborate 、 Pseudomonas cepacia lipase PS 、 sodium methylate 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 7,11-epoxymegastigma-5(6)-en-9-ol
  参考文献：
  名称：

  Synthesis and olfactory evaluation of the enantiomerically enriched forms of 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols isomers, identified in Passiflora edulis

  摘要：

  A study on the synthesis of the isomers of the natural C-13 norterpenoids derivatives 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols is reported. The latter compounds were prepared from readily available racemic alpha-ionone and then resolved by mean of lipase-mediated acetylation. The obtained enantiomerically forms were evaluated for their odour properties. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.02.021

文献信息

• Synthesis and olfactory evaluation of the enantiomerically enriched forms of 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols isomers, identified in Passiflora edulis
  作者：Elisabetta Brenna、Claudio Fuganti、Stefano Serra

  DOI：10.1016/j.tetasy.2005.02.021

  日期：2005.5

  A study on the synthesis of the isomers of the natural C-13 norterpenoids derivatives 7,11-epoxymegastigma-5(6)-en-9-one and 7,11-epoxymegastigma-5(6)-en-9-ols is reported. The latter compounds were prepared from readily available racemic alpha-ionone and then resolved by mean of lipase-mediated acetylation. The obtained enantiomerically forms were evaluated for their odour properties. (C) 2005 Elsevier Ltd. All rights reserved.