4-(2-iodophenyl)butan-1-ol | 1093413-28-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-iodophenyl)butan-1-ol
• 英文别名: 4-(o-iodophenyl)butan-1-ol
• CAS: 1093413-28-5
• 化学式: C₁₀H₁₃IO
• 分子量: 276.117
• InChiKey: WOYWNTKUAAKCDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2-iodophenyl)butan-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以95%的产率得到4-(2-碘苯基)丁醛
  参考文献：
  名称：

  Generation of Medium-Ring Cycloalkynes by Ring Expansion of Vinylogous Acyl Triflates

  摘要：

  Reductive cyclization of aryl and vinyl iodides tethered to vinylogous acyl trifiates (VATS) induces a ring-expanding fragmentation to provide cyclic alkynyl ketones, including strained nine-membered cycloalkynes, in fair to excellent yield. The tandem cyclization/C-C bond-cleavage is Initiated under carefully optimized conditions by halogen metal exchange in the presence of carbonyl and vinyl triflate functionality. A modified protocol for alkylation of 1,3-cyclohexanedione is described for preparing the relevant VAT substrates.

  DOI：

  10.1021/ol2003308
• 作为产物：
  描述：

  1-碘-2-(2-碘乙基)-苯 在 水 、 sodium hydride 、 二异丁基氢化铝 、 sodium chloride 作用下， 以 四氢呋喃 、 二甲基亚砜 、 甲苯 为溶剂， 生成 4-(2-iodophenyl)butan-1-ol
  参考文献：
  名称：

  Generation of Medium-Ring Cycloalkynes by Ring Expansion of Vinylogous Acyl Triflates

  摘要：

  Reductive cyclization of aryl and vinyl iodides tethered to vinylogous acyl trifiates (VATS) induces a ring-expanding fragmentation to provide cyclic alkynyl ketones, including strained nine-membered cycloalkynes, in fair to excellent yield. The tandem cyclization/C-C bond-cleavage is Initiated under carefully optimized conditions by halogen metal exchange in the presence of carbonyl and vinyl triflate functionality. A modified protocol for alkylation of 1,3-cyclohexanedione is described for preparing the relevant VAT substrates.

  DOI：

  10.1021/ol2003308

文献信息

• A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc
  作者：Tetsuji Kubo、Chiharu Katoh、Ken Yamada、Kentaro Okano、Hidetoshi Tokuyama、Tohru Fukuyama

  DOI：10.1016/j.tet.2008.09.042

  日期：2008.12

  combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical

  发现CuI和CsOAc的独特组合在温和条件下催化芳基胺化。该反应在室温或90°C下进行，具有广泛的官能团相容性。分子内反应能够形成在氮原子上具有各种保护基的五元，六元和七元环。研究了分子间胺化的范围及其在不对称的N，N'-二烷基化苯二胺上的应用。
• Image bearing member, method of manufacturing the same, image formation method, image forming apparatus and process cartridge
  申请人：Nagai Kazukiyo

  公开号：US20080304867A1

  公开（公告）日：2008-12-11

  An image bearing member including an electroconductive substrate, a photosensitive layer located overlying the electroconductive substrate and a cross linking surface layer comprising a charge transport curing compound and located overlying the photosensitive layer, wherein the charge transport curing compound includes a material including a structure unit represented by the following Chemical formula A: Chemical formula A where R 1 to R 5 and R 1 ′ to R 5 ′ independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, R 6 represents a hydrogen atom or a methyl group and X represents an alkylene group having a straight chain or a branched chain having 2 to 5 carbon atoms.

  一种图像承载成员，包括导电基底、位于导电基底上方的感光层和包括电荷传输固化化合物、位于感光层上方的交联表面层，其中电荷传输固化化合物包括一种材料，该材料包括以下化学式A所表示的结构单元： 化学式A 其中R1至R5和R1'至R5'独立地表示氢原子、具有1至4个碳原子的烷基或具有1至4个碳原子的烷氧基，R6表示氢原子或甲基基团，X表示具有2至5个碳原子的直链或支链烷基。
• Facile Synthesis of [1,2,3]-Triazole-Fused Isoindolines, Tetrahydroisoquino­lines, Benzoazepines and Benzoazocines by Palladium-Copper Catalysed Heterocyclisation­
  作者：Chinmay Chowdhury、Kaushik Brahma、Basudeb Achari

  DOI：10.1055/s-0032-1316839

  日期：——

  An elegant method for the synthesis of 1,2,3-triazoles fused with five-, six-, seven- and eight-membered benzoheterocycles, including isoindoline, tetrahydroisoquinoline, benzoazepine and benzoazocine, has been developed via palladium-copper catalysed reactions in one-pot. The broad scope of this reaction was illustrated by effecting bis-heteroannulations, synthesis of uracil derivatives of biological interest, and employment of acetylene gas as an inexpensive substrate. The reactions are experimentally simple and utilise easily accessible substrates of different types.
• Suzuki–Miyaura Coupling Reactions of Conjunctive Reagents: 2-Borylated Allylic Sulfones
  作者：Erich F. Altenhofer、Michael Harmata

  DOI：10.1021/acs.joc.5b01253

  日期：2015.8.21

  In support of various efforts in our group, we developed methods for the convenient Suzuki-Miyaura coupling of borylated allylic sulfones with various electrophiles in both inter- and the less common intramolecular modes. The procedure facilitates the preparation of a wide variety of sulfones in a straightforward fashion, including six- through eight-membered rings.