(Z)-1,1,1-Trifluoro-5-(trimethylsilyl)-4-pentene-2-ol | 1011253-77-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (Z)-1,1,1-Trifluoro-5-(trimethylsilyl)-4-pentene-2-ol
• 英文别名: (Z)-1,1,1-trifluoro-5-trimethylsilylpent-4-en-2-ol
• CAS: 1011253-77-2
• 化学式: C₈H₁₅F₃OSi
• 分子量: 212.287
• InChiKey: GCUZXSPTRABZGX-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-1,1,1-Trifluoro-5-(trimethylsilyl)-4-pentene-2-ol 、 正辛醛 在 indium(III) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 66.0h， 以55%的产率得到
  参考文献：
  名称：

  Rapid access to CF3-containing heterocycles

  摘要：

  The silyl-Prins and aza-silyl-Prins reactions have been employed for the preparation of 6-CF3-substituted dihydropyrans and 6-CF3-substituted tetrahydropyridines. The product heterocycles have been further elaborated to a number of products, including CF3-substituted pipecolates and hydroxylated pyrans and piperidines. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.178
• 作为产物：
  描述：

  1,1,1-Trifluoro-5-trimethylsilanyl-pent-4-yn-2-ol 在 二异丁基氢化铝 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 24.0h， 以61%的产率得到(Z)-1,1,1-Trifluoro-5-(trimethylsilyl)-4-pentene-2-ol
  参考文献：
  名称：

  Rapid access to CF3-containing heterocycles

  摘要：

  The silyl-Prins and aza-silyl-Prins reactions have been employed for the preparation of 6-CF3-substituted dihydropyrans and 6-CF3-substituted tetrahydropyridines. The product heterocycles have been further elaborated to a number of products, including CF3-substituted pipecolates and hydroxylated pyrans and piperidines. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.178

文献信息

• Rapid access to CF3-containing heterocycles
  作者：Adrian P. Dobbs、Robert J. Parker、John Skidmore

  DOI：10.1016/j.tetlet.2007.11.178

  日期：2008.1

  The silyl-Prins and aza-silyl-Prins reactions have been employed for the preparation of 6-CF3-substituted dihydropyrans and 6-CF3-substituted tetrahydropyridines. The product heterocycles have been further elaborated to a number of products, including CF3-substituted pipecolates and hydroxylated pyrans and piperidines. (C) 2007 Elsevier Ltd. All rights reserved.