5-庚基-1H-咪唑 | 260050-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-庚基-1H-咪唑
• 英文名称: 5-Heptyl-1H-imidazole
• CAS: 260050-43-9
• 化学式: C₁₀H₁₈N₂
• mdl: MFCD18808319
• 分子量: 166.266
• InChiKey: DGQRKRRQEVBDKW-UHFFFAOYSA-N

物化性质

• 沸点：
  313.2±11.0 °C(Predicted)
• 密度：
  0.942±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-庚基-1H-咪唑 、 碘甲烷 在 苯甲酰氯 作用下， 生成 1-methyl-5-n-heptylimidazole
  参考文献：
  名称：

  Carpene; Collon; Remaury, Journal of Pharmacology and Experimental Therapeutics, 1995, vol. 272, # 2, p. 681 - 688

  摘要：

  DOI：
• 作为产物：
  描述：

  壬醛 以 乙醚 、 乙醇 为溶剂， 生成 5-庚基-1H-咪唑
  参考文献：
  名称：

  Carpene; Collon; Remaury, Journal of Pharmacology and Experimental Therapeutics, 1995, vol. 272, # 2, p. 681 - 688

  摘要：

  DOI：

文献信息

• Lithiation and Alkylation of the Imidazole Backbone
  作者：Frida Johanne Lundevall、Hans‐René Bjørsvik

  DOI：10.1002/ejoc.202201504

  日期：2023.5.12

  A method for the alkylation of the imidazole backbone has been developed. Imidazole was protected with tetrahydro-2H-pyran-2-yl and chloro groups, respectively. The backbone (position 5) of imidazole was then lithiated and alkylated with haloalkanes, aldehydes, and ketones. The protective groups were removed by treatment with acid and base and hydrogenation. The method proved good functional group

  已经开发了一种用于咪唑主链烷基化的方法。咪唑分别用四氢-2H-吡喃-2-基和氯基保护。然后将咪唑的主链（5 位）锂化并用卤代烷烃、醛和酮进行烷基化。通过用酸和碱处理以及氢化除去保护基团。该方法证明具有良好的官能团耐受性。
• Modified nucleotides and uses thereof
  申请人：Singular Genomics Systems, Inc.

  公开号：US11174281B1

  公开（公告）日：2021-11-16

  Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.

  本文特别公开了化合物、修饰核苷酸、组合物以及使用它们的方法。
• Synthesis and histamine H3 receptor activity of 4-(n-alkyl)-1H-imidazoles and 4-(ω-phenylalkyl)-1H-imidazoles
  作者：Iwan J.P De Esch、Aziz Gaffar、Wiro M.P.B Menge、Henk Timmerman

  DOI：10.1016/s0968-0896(99)00253-9

  日期：1999.12

  The influence of lipophilic moieties attached to a 4-1H-imidazole ring on the histamine H-3 receptor activity was systematically investigated. Series of 4-(n-alkyl)-1H-imidazoles and 4-(omega-phenylalkyl)-1H-imidazoles were prepared, with an alkyl chain varying from 2-9 methylene groups and from 1-9 methylene groups, respectively. The compounds were tested for their activity on the H-3 receptor under in vitro conditions. For the 4-(n-alkyl)-1H-imidazoles the activity is proportional to chain length, ranging from a pA(2) value of 6.3 +/- 0.2 for 4-(n-propyl)-1H-imidazoIe to a pA(2) value of 7.2 +/- 0.1 for 4-(n-decyl)-1H-imidazole. For the series 4-(omega-phenylalkyl)-4H-imidazoles an optimum in H-3 activity was found for the pentylene spacer: 4-(omega-phenylpentyl)-1H-imidazole has a pA(2) value of 7.8 +/- 0.1. (C) 1999 Elsevier Science Ltd. All rights reserved.
• ADHESIVE COMPOSITION
  申请人：SUWA Tatsuhiro

  公开号：US20120108733A1

  公开（公告）日：2012-05-03

  An adhesive composition, an optical member, a surface protective film, and an adhesive sheet, the adhesive composition including 100 parts by weight of a (meth)acrylic copolymer having a weight average molecular weight of about 100,000 to about 2,000,000 g/mol; about 0.05 to about 5 parts by weight of a carbodiimide crosslinker, based on 100 parts by weight of the (meth)acrylic copolymer; and about 0.001 to about 5 parts by weight of an imidazole compound represented by Formula 1, based on 100 parts by weight of the (meth)acrylic copolymer: wherein, in Formula 1, R 1 , R 2 , and R 3 are each independently a hydrogen atom, a halogen atom, or a substituted or unsubstituted C1 to C10 straight or branched alkyl group.
• ADHESIVE COMPOSITION, ADHESIVE LAYER, OPTICAL MEMBER, AND ADHESIVE SHEET
  申请人：OGAWA Hirosh

  公开号：US20120309873A1

  公开（公告）日：2012-12-06

  An adhesive composition, an adhesive layer, an optical member, and an adhesive sheet, the adhesive composition including 100 parts by weight of a (meth)acrylic copolymer, the (meth)acrylic copolymer having a weight average molecular weight of about 100,000 to about 2,000,000 g/mol; about 0.05 to about 5 parts by weight of a carbodiimide crosslinker; and about 0.01 to about 0.3 parts by weight of an organic group-containing compound, the organic group-containing compound including at least one selected from the group of titanium, zirconium, and hafnium.