methyl α-D-xylopyranoside 4-methyl ether | 58918-58-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl α-D-xylopyranoside 4-methyl ether
• 英文别名: (2S,3R,4R,5R)-2,5-dimethoxyoxane-3,4-diol
• CAS: 58918-58-4
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: PDEWKECWEITUPI-UCROKIRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲基-Alpha-D-吡喃木糖 、 碘甲烷 在 二正丁基氧化锡 作用下， 生成 methyl α-D-xylopyranoside 2-methyl ether 、 methyl α-D-xylopyranoside 4-methyl ether
  参考文献：
  名称：

  Haque, Mohammed Ekramul; Kikuchi, Tohru; Yoshimoto, Kimihiro, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 6, p. 2243 - 2255

  摘要：

  DOI：

文献信息

• NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem

  公开号：EP1554299A2

  公开（公告）日：2005-07-20
• [EN] NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS<br/>[FR] NOUVEAUX DERIVES DE PENTOSES UTILISES EN TANT DE MEDICAMENTS ANTI-HYPERGLYCEMIQUES
  申请人：YISSUM RES DEV CO

  公开号：WO2004034960A2

  公开（公告）日：2004-04-29

  The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.
• Haque, Mohammed Ekramul; Kikuchi, Tohru; Yoshimoto, Kimihiro, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 6, p. 2243 - 2255
  作者：Haque, Mohammed Ekramul、Kikuchi, Tohru、Yoshimoto, Kimihiro、Tsuda, Yoshisuke

  DOI：——

  日期：——