3-Benzoyl-chinuclidin | 57734-94-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Benzoyl-chinuclidin
• 英文别名: Methanone, 1-azabicyclo[2.2.2]oct-3-ylphenyl-；1-azabicyclo[2.2.2]octan-3-yl(phenyl)methanone
• CAS: 57734-94-8
• 化学式: C₁₄H₁₇NO
• 分子量: 215.295
• InChiKey: XZQHUOUQAUYEOU-UHFFFAOYSA-N

物化性质

• 沸点：
  331.7±25.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Benzoyl-chinuclidin 以50%的产率得到
  参考文献：
  名称：

  KAMINKA M. EH.; MIXLINA E. E.; VOROBEVA V. YA.; YANINA A. D.; KOMAROVA N.+, XIM.-FARMATSEVT. ZH., 1977, 11, HO 2, 24-28

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS DE LA CHOLINE KINASE
  申请人：VERTEX PHARMA

  公开号：WO2013043960A1

  公开（公告）日：2013-03-28

  The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及作为胆碱激酶抑制剂的化合物。该发明还提供包含所述化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病、疾病或紊乱的方法。该发明还提供制备本发明化合物的方法。
• [EN] COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS DE CHOLINE KINASE
  申请人：VERTEX PHARMA

  公开号：WO2013043961A1

  公开（公告）日：2013-03-28

  The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及作为胆碱激酶抑制剂的化合物。该发明还提供包含所述化合物的药学上可接受的组合物，并提供使用这些组合物治疗各种疾病、状况或障碍的方法。该发明还提供制备本发明化合物的方法。
• COMPOUNDS USEFUL AS INHIBITORS OF CHOLINE KINASE
  申请人：Everitt Simon

  公开号：US20130261114A1

  公开（公告）日：2013-10-03

  The present invention relates to compounds useful as inhibitors of choline kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作胆碱激酶抑制剂的化合物。本发明还提供了包括所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病、状况或障碍的方法。本发明还提供了制备本发明中化合物的方法。
• Synthesis, stereochemistry, and pharmacology of some new (3-quinuclidyl) diheteroaryl- and aryl heteroaryl carbinols
  作者：O. R. Arbuzova、K. F. Turchin、S. M. Tupikina、M. L. Zhirnikova、E. E. Mikhlina、M. É. Kaminka、L. N. Yakhontov

  DOI：10.1007/bf00766880

  日期：1986.1

  The investigation of the antisecretory and antiulcer activity was performed on hybrid male rats. The influence of the compounds on the gastric secretory function was determined by the method of Shai in the modification of Meyer. Gastric ulcers were induced in the rats by the single ip application of 30 mg of histamine. The data obtained indicate that compound (Ic.HCI) shows antisecretory action. Analysis

  对杂交雄性大鼠进行抗分泌和抗溃疡活性的研究。化合物对胃分泌功能的影响采用Meyer修饰的Shai法测定。通过单次腹膜内施用30mg组胺在大鼠中诱发胃溃疡。获得的数据表明化合物（Ic.HCl）显示出抗分泌作用。关于二呋喃基和二噻吩基衍生物中由 Eu (DPM)/sub 3/ 引起的质子化学位移的分析表明，c/sub 9/ 处的其他两个取代基可以根据给定取代基的旋转子引起的位移。
• Synthesis and pharmacological investigation of 3-quinuclidyl dialkyl, diheteryl, and cycloalkylaryl carbinols
  作者：M. É. Kaminka、E. E. Mikhlina、V. Ya. Vorob'eva、A. D. Yanina、N. A. Komarova、M. D. Mashkovskii、L. N. Yakhontov

  DOI：10.1007/bf00779072

  日期：1977.2