4-氨基-N-(4-氨基苯基)-N-甲基苯甲酰胺 | 58338-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-N-(4-氨基苯基)-N-甲基苯甲酰胺
• 英文名称: 4-amino-N-(4-aminophenyl)-N-methylbenzamide
• 英文别名: N(1)-(4-Aminobenzoyl)-N(1)-methyl-1.4-diaminobenzol
• CAS: 58338-54-8
• 化学式: C₁₄H₁₅N₃O
• 分子量: 241.293
• InChiKey: HBMFWHCRYKDNCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  72.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  BOC-L-脯氨酸 、 4-氨基-N-(4-氨基苯基)-N-甲基苯甲酰胺 在 盐酸 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 (2S)-N-[4-[methyl-[4-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]phenyl]carbamoyl]phenyl]-1-(2-phenylacetyl)pyrrolidine-2-carboxamide
  参考文献：
  名称：

  HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies

  摘要：

  In a recent disclosure,(1) we described the discovery of dimeric, prolinamide-based NS5A replication complex inhibitors exhibiting excellent potency towards an HCV genotype 1b replicon. That disclosure dealt with the SAR exploration of the peripheral region of our lead chemotype, and herein is described the SAR uncovered from a complementary effort that focused on the central core region. From this effort, the contribution of the core region to the overall topology of the pharmacophore, primarily vector orientation and planarity, was determined, with a set of analogs exhibiting < 10 nM EC50 in a genotype 1b replicon assay. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.086
• 作为产物：
  描述：

  N-甲基-4-硝基-N-(4-硝基苯基)苯甲酰胺 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 生成 4-氨基-N-(4-氨基苯基)-N-甲基苯甲酰胺
  参考文献：
  名称：

  HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies

  摘要：

  In a recent disclosure,(1) we described the discovery of dimeric, prolinamide-based NS5A replication complex inhibitors exhibiting excellent potency towards an HCV genotype 1b replicon. That disclosure dealt with the SAR exploration of the peripheral region of our lead chemotype, and herein is described the SAR uncovered from a complementary effort that focused on the central core region. From this effort, the contribution of the core region to the overall topology of the pharmacophore, primarily vector orientation and planarity, was determined, with a set of analogs exhibiting < 10 nM EC50 in a genotype 1b replicon assay. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.086

文献信息

• Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer
  申请人：JNC CORPORATION

  公开号：US10968392B2

  公开（公告）日：2021-04-06

  Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display quality even when exposed to strong light for a long period of time. To provide these, used is a liquid crystal aligning agent for photoalignment which contains a polymer having a structural unit containing a photoreactive structure and in which the structural unit containing a photoreactive structure undergoes chemical reaction by heating.

  提供了一种液晶取向膜，能够通过光取向获得各向异性，并且对光稳定，并且提供了一种液晶显示装置，即使长时间暴露在强光下也能保持高电压保持比率而不会降低显示质量。为了实现这些，使用了一种用于光取向的液晶取向剂，其中包含具有光反应结构的结构单元的聚合物，并且具有光反应结构的结构单元通过加热发生化学反应。
• LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：JNC Corporation

  公开号：EP3125033A1

  公开（公告）日：2017-02-01

  Subject The subject is to provide liquid crystal display device that has characteristics such as a short response time, a large voltage holding ratio, a low threshold voltage, a large contrast ratio, a long service life and a small flicker rate. Means for solution The invention relates to a liquid crystal display device including an electrode group formed on one or both of a pair of substrates that are opposed to each other, and a plurality of active devices connected to the electrode group, and a liquid crystal alignment film formed on the opposing surfaces of the pair of substrates, and a liquid crystal composition sandwiched in between the pair of substrates.

  主题 本课题旨在提供具有响应时间短、电压保持比大、阈值电压低、对比度大、使用寿命长和闪烁率小等特性的液晶显示装置。 解决方法 本发明涉及一种液晶显示装置，包括在一对相对的基板中的一个或两个上形成的电极组，以及连接到电极组的多个有源器件，和在这对基板的相对表面上形成的液晶配向膜，以及夹在这对基板之间的液晶成分。
• Liquid crystal display device
  申请人：JNC CORPORATION

  公开号：US10041000B2

  公开（公告）日：2018-08-07

  The subject is to show liquid crystal display device that has characteristics such as a short response time, a large voltage holding ratio, a low threshold voltage, a large contrast ratio, a long service life and a small flicker rate. The disclosure relates to a liquid crystal display device including an electrode group formed on one or both of a pair of substrates that are opposed to each other, and a plurality of active devices connected to the electrode group, and a liquid crystal alignment film formed on the opposing surfaces of the pair of substrates, and a liquid crystal composition sandwiched in between the pair of substrates.

  本发明的主题是显示具有响应时间短、电压保持比大、阈值电压低、对比度大、使用寿命长和闪烁率小等特性的液晶显示装置。本公开涉及一种液晶显示装置，包括形成在一对相对的基板中的一个或两个上的电极组，以及连接到电极组的多个有源器件，和形成在这对基板的相对表面上的液晶配向膜，以及夹在这对基板之间的液晶成分。
• [DE] VERFAHREN ZUR HERSTELLUNG VON ISOCYANATEN AUS SCHWERLÖSLICHEN PRIMÄREN AMINEN<br/>[EN] PROCESS FOR PREPARING ISOCYANATES FROM PRIMARY AMINES WHICH ARE NOT READILY DISSOLVED<br/>[FR] PROCEDE DE PREPARATION D'ISOCYANATES A PARTIR D'AMINES PRIMAIRES DIFFICILEMENT SOLUBLES
  申请人：BAYER AKTIENGESELLSCHAFT

  公开号：WO1998025888A1

  公开（公告）日：1998-06-18

  (DE) Isocyanate werden durch 'Kalt-Heiß-Phosgenierung' von in Chlorbenzol und/oder o-Dichlorbenzol schwerlöslichen primären Aminen hergestellt, in dem man Phosgen in einem aus Chlorbenzol und/oder o-Dichlorbenzol bestehenden Lösungsmittel A löst, das umzusetzende Amin in einem zweiten zur Lösung des Amins geeigneten inerten aprotischen Lösungsmittel B gegebenenfalls bei erhöhter Temperatur ebenfalls löst, wobei das Lösungsmittel B mit dem Lösungsmittel A mischbar ist und einen mindestens 30 °C höheren Siedepunkt als das Lösungsmittel A und einen mindestens 30 °C niedrigeren Siedepunkt als das herzustellende Isocyanat besitzt, die so hergestellte Aminlösung mit der Phosgenlösung bei Temperaturen von 10 bis 60 °C vermischt und das Gemisch in bekannter Weise durch Temperaturerhöhung bei 130 bis 200 °C zur Umsetzung bringt.(EN) Isocyanates are prepared by the 'cold-hot phosgenation' of primary amines which are not readily dissolved in chlorobenzene and/or o-dichlorobenzene. According to this process phosgene is dissolved in a solvent (A) consisting of chlorobenzene and/or o-dichlorobenzene. The amine to be reacted is likewise dissolved, optionally at a high temperature, in a second inert aprotic solvent (B) which is suitable for dissolving the amine, the solvent (B) being miscible with the solvent (A) and having a boiling point which is at least 30 °C higher than that of solvent (A) and a boiling point which is least 30 °C lower than that of the isocyanate to be prepared. The resultant amine solution is mixed with the phosgene solution at temperatures of between 10 and 60 °C, and the mixture reacted in known manner at between 130 and 200 °C by increasing the temperature.(FR) L'invention concerne un procédé de préparation d'isocyanates obtenus par phosgénation 'à froid-à chaud' d'amines primaires difficilement solubles dans du chlorobenzène et/ou du o-dichlorobenzène. Selon ce procédé, du phosgène est dissous dans un solvant A composé de chlorobenzène et/ou de o-dichlorobenzène, l'amine à faire réagir est également dissoute dans un second solvant B aprotique inerte adapté à la dissolution de l'amine, le cas échéant à température plus élevée, le solvant B étant miscible avec le solvant A et présentant un point d'ébullition dépassant d'au moins 30 °C celui du solvant A et un point d'ébullition inférieur d'au moins 30 °C à celui de l'isocyanate à préparer. La solution d'amine ainsi obtenue est mélangée avec la solution de phosgène à des températures comprises entre 10 et 60 °C et le mélange est mis à réagir de manière connue en soi par augmentation de la température, entre 130 et 200 °C.

  有关于这些直氮酸的确定，涉及通过“冷-热磷酸化”法制备。有关制备方案： 直氮酸通过“冷-热磷酸化”法制备，其过程为：将磷gene（用于该过程），在氯苯和/或二氯苯的溶液A中溶解（该溶剂A由氯苯和/或二氯苯组成），并且可能进一步提高温度。释放活动岳活的是无机 inert溶剂B，该溶剂B可与溶剂A混合，且其在无变化温度下溶液A的基础上，沸点至少升高30°C，同时其沸点必须低于目标直氮酸至少30°C，否则无法制造而得。 所得胺溶液与磷酸液混合于10至60°C间，之后经升温至130至200°C时，混合液通过升高温度反应得到所需的产物。
• LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3125033B1

  公开（公告）日：2021-06-02