4,4,5-trimethyl-3a,6a-dihydro-3H-cyclopenta[b]furan-2-one | 852659-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 4,4,5-trimethyl-3a,6a-dihydro-3H-cyclopenta[b]furan-2-one
• CAS: 852659-11-1
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: NGBBYSKITGHMGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4,5-trimethyl-3a,6a-dihydro-3H-cyclopenta[b]furan-2-one 生成 C₁₀H₁₆O₂
  参考文献：
  名称：

  [EN] NOVEL CYCLIC OXYGENATED COMPOUNDS HAVING COOLING, FRAGRANCE, AND FLAVOR PROPERTIES, AND USES THEREOF
  [FR] NOUVEAUX COMPOSES CYCLIQUES OXYGENES POSSEDANT DES PROPRIETES DE RAFRAICHISSEMENT, DE FRAGRANCE ET DE SAVEUR, ET UTILISATIONS DESDITS COMPOSES

  摘要：

  公开号：

  WO2005049562A3
• 作为产物：
  描述：

  2-氧代-delta(3)-4,5,5-三甲基环戊烯基乙酸 生成 4,4,5-trimethyl-3a,6a-dihydro-3H-cyclopenta[b]furan-2-one
  参考文献：
  名称：

  [EN] NOVEL CYCLIC OXYGENATED COMPOUNDS HAVING COOLING, FRAGRANCE, AND FLAVOR PROPERTIES, AND USES THEREOF
  [FR] NOUVEAUX COMPOSES CYCLIQUES OXYGENES POSSEDANT DES PROPRIETES DE RAFRAICHISSEMENT, DE FRAGRANCE ET DE SAVEUR, ET UTILISATIONS DESDITS COMPOSES

  摘要：

  公开号：

  WO2005049562A3

文献信息

• [EN] KETOCAMPHOLENIC ACID DERIVATIVES AND THEIR USE IN FRAGRANCE APPLICATIONS<br/>[FR] DERIVES D'ACIDE CETOCAMPHOLENIQUE ET LEUR UTILISATION DANS DES APPLICATIONS DE FRAGRANCE
  申请人：AROMAGEN CORP

  公开号：WO2004013079A1

  公开（公告）日：2004-02-12

  Ketocampholenic acid derivatives, their use, and methods of preparing these derivatives are described. In one aspect, novel derivatives of 2-oxo-4,5,5-trimethylcyclopent-3-enylacetic acid (herein further referred as ketocampholenic acid or KCA), which is a natural product that may be prepared by microbial biological oxidation of camphor or of a suitable precursor, are described. Novel derivative compounds may be prepared according to the methods described in the present invention. Such derivative olfactory properties that make them useful in fragrance and flavor applications.

  描述了Ketocampholenic酸衍生物、它们的用途以及制备这些衍生物的方法。在一个方面，描述了2-氧代-4,5,5-三甲基环戊-3-烯基乙酸（以下简称为Ketocampholenic酸或KCA）的新衍生物，这是一种天然产物，可以通过对藿香脑或适当前体进行微生物生物氧化来制备。根据本发明描述的方法可以制备新的衍生物化合物。这些衍生物具有使它们在香味和风味应用中有用的嗅觉特性。
• Novel Cyclic Oxygenated Compounds Having Cooling, Fragrance, and Flavor Properties, and Uses Thereof
  申请人：Selifonov Sergey

  公开号：US20070274928A1

  公开（公告）日：2007-11-29

  Compositions that include compounds capable of producing a cooling sensory effect such as certain hydroxy-ketones and hydroxy-aldehyde compounds, their cyclic semi-ketals and semiacetals, and other derivatives thereof. The compounds impart a refreshing and cooling sensation of long duration and high potency, and thus are useful in a variety of formulations, including consumer products such as mouth formulations, food and beverage products, tobacco and smoking articles, fragrances, toiletries, ointments, and the like.

  这段话的意思是：包括某些羟基酮和羟基醛化合物、它们的环状半酮和半缩醛以及其他衍生物在内的化合物，可以产生冷却感官效应的组合物。这些化合物具有长时间和高效的清爽和冷却感觉，因此在各种配方中非常有用，包括消费品如口腔制剂、食品和饮料制品、烟草和吸烟用品、香水、化妆品、药膏等。
• [EN] NOVEL CYCLIC OXYGENATED COMPOUNDS HAVING COOLING, FRAGRANCE, AND FLAVOR PROPERTIES, AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSES CYCLIQUES OXYGENES POSSEDANT DES PROPRIETES DE RAFRAICHISSEMENT, DE FRAGRANCE ET DE SAVEUR, ET UTILISATIONS DESDITS COMPOSES
  申请人：AROMAGEN CORP

  公开号：WO2005049562A3

  公开（公告）日：2005-10-06