N-[(5,6-dimethoxypyridin-2-yl)methyl]-5-(5-methylpyridin-3-yl)-2,2'-bipyrazine-3-carboxylamide | 1256921-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[(5,6-dimethoxypyridin-2-yl)methyl]-5-(5-methylpyridin-3-yl)-2,2'-bipyrazine-3-carboxylamide
• 英文别名: N-[(5,6-dimethoxypyridin-2-yl)methyl]-6-(5-methylpyridin-3-yl)-3-pyrazin-2-ylpyrazine-2-carboxamide
• CAS: 1256921-62-6
• 化学式: C₂₃H₂₁N₇O₃
• 分子量: 443.465
• InChiKey: DWDLCRJEWZGCHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (5,6-二甲氧基吡啶-2-基)甲胺 、 methyl 5-(5-methylpyridin-3-yl)-2,2'-bipyrazine-3-carboxylate 在 potassium trimethylsilonate 、 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 N-[(5,6-dimethoxypyridin-2-yl)methyl]-5-(5-methylpyridin-3-yl)-2,2'-bipyrazine-3-carboxylamide
  参考文献：
  名称：

  [EN] PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS
  [FR] PYRAZINE CARBOXAMIDE ANTAGONISTES DU RÉCEPTEUR DE L'OREXINE

  摘要：

  本发明涉及吡嗪羧酰胺化合物，这些化合物是促进睡眠素受体的拮抗剂，可用于治疗或预防涉及促进睡眠素受体的神经学和精神疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及促进睡眠素受体的疾病中的用途。

  公开号：

  WO2010141275A1

文献信息

• Corrosion Inhibitors Having Increased Biodegradability and Reduced Toxicity
  申请人：Leinweber Dirk

  公开号：US20100234592A1

  公开（公告）日：2010-09-16

  The invention relates to the use of salts of compounds of the formula (1) and amines of the formula (2) where R 1 is C 1 - to C 30 -alkyl, C 2 - to C 30 -alkenyl, C 6 - to C 30 -aryl or C 7 - to C 30 -alkylaryl, R 2 is C 1 - to C 30 -alkyl, C 2 - to C 30 -alkenyl, C 6 - to C 30 -aryl or C 7 - to C 30 -alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, and R 3 and R 4 are each independently hydrogen, C 1 - to C 30 -alkyl, C 2 - to C 30 -alkenyl, C 6 - to C 30 -aryl or C 7 - to C 30 -alkylaryl, or an optionally heteroatom containing organic radical having from 1 to 30 carbon atoms, where R 3 and R 4 can also form, with the inclusion of the nitrogen atom, a ring having from 5 to 7 ring atoms.

  本发明涉及使用公式（1）化合物的盐和公式（2）胺的用途，其中R1为C1-至C30-烷基，C2-至C30-烯基，C6-至C30-芳基或C7-至C30-烷基芳基，R2为C1-至C30-烷基，C2-至C30-烯基，C6-至C30-芳基或C7-至C30-烷基芳基，或具有1至30个碳原子的可选择含杂原子的有机基团，R3和R4各自独立地为氢，C1-至C30-烷基，C2-至C30-烯基，C6-至C30-芳基或C7-至C30-烷基芳基，或具有1至30个碳原子的可选择含杂原子的有机基团，其中R3和R4还可以与氮原子一起形成具有5至7个环原子的环。
• PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS
  申请人：Mercer Swati P.

  公开号：US20120065205A1

  公开（公告）日：2012-03-15

  The present invention is directed to pyrazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对草酰吡嗪类化合物的研究，这些化合物是促进睡眠激素受体的拮抗剂，可用于治疗或预防神经系统和精神疾病，以及与促进睡眠激素受体有关的疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗与促进睡眠激素受体有关的疾病方面的使用。
• [EN] PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] PYRAZINE CARBOXAMIDE ANTAGONISTES DU RÉCEPTEUR DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2010141275A1

  公开（公告）日：2010-12-09

  The present invention is directed to pyrazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及吡嗪羧酰胺化合物，这些化合物是促进睡眠素受体的拮抗剂，可用于治疗或预防涉及促进睡眠素受体的神经学和精神疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及促进睡眠素受体的疾病中的用途。