2-phenyl-4-chloro-5-(4-aminophenylthio)pyridazin-3(2H)-one | 496785-25-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-phenyl-4-chloro-5-(4-aminophenylthio)pyridazin-3(2H)-one
• 英文别名: SKI-181612；5-(4-Aminophenyl)sulfanyl-4-chloro-2-phenylpyridazin-3-one
• CAS: 496785-25-2
• 化学式: C₁₆H₁₂ClN₃OS
• 分子量: 329.81
• InChiKey: IXXPFHOXPJQNGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-phenyl-4-chloro-5-(4-aminophenylthio)pyridazin-3(2H)-one 、 4-氯苯甲醛 、 亚磷酸酯二正丙脂 以 甲苯 为溶剂， 反应 7.0h， 以67%的产率得到4-Chloro-5-[4-[[(4-chlorophenyl)-dipropoxyphosphorylmethyl]amino]phenyl]sulfanyl-2-phenylpyridazin-3-one
  参考文献：
  名称：

  Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety

  摘要：

  The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O'-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].

  DOI：

  10.1080/10426507.2010.482543
• 作为产物：
  描述：

  苯肼 在 potassium carbonate 、 溶剂黄146 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 2-phenyl-4-chloro-5-(4-aminophenylthio)pyridazin-3(2H)-one
  参考文献：
  名称：

  Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety

  摘要：

  The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O'-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].

  DOI：

  10.1080/10426507.2010.482543

文献信息

• PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS
  申请人：Djaballah Hakim

  公开号：US20100210649A1

  公开（公告）日：2010-08-19

  The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing these compounds, methods of syntheses, and a method of treatment of a proliferative disease in a subject by administration of a therapeutically effective amount of a compound of formulae (I) or (II). Both classes of compounds were identified through screening of a collection of small molecule libraries.

  本发明涉及式(I)的吡啶二酮化合物和式(II)的呋喃化合物，以及式(I)和(II)化合物的制药组合物、包含这些化合物的试剂盒、合成方法，以及通过给予式(I)或(II)化合物的治疗有效量来治疗受体内增生性疾病的方法。这两类化合物是通过筛选小分子库的集合而确定的。
• US9562019B2
  申请人：——

  公开号：US9562019B2

  公开（公告）日：2017-02-07
• Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety
  作者：Jun Zhou、Hui-Tao Fan、Bao-An Song、Lin-Hong Jin、Pinaki S. Bhadury、De-Yu Hu、Song Yang

  DOI：10.1080/10426507.2010.482543

  日期：2010.12.30

  The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O'-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].