4-Chloro-5-[4-[[diethoxyphosphoryl-(2-methoxyphenyl)methyl]amino]phenyl]sulfanyl-2-phenylpyridazin-3-one | 1268514-89-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-Chloro-5-[4-[[diethoxyphosphoryl-(2-methoxyphenyl)methyl]amino]phenyl]sulfanyl-2-phenylpyridazin-3-one
• CAS: 1268514-89-1
• 化学式: C₂₈H₂₉ClN₃O₅PS
• 分子量: 586.048
• InChiKey: FNVHXJMMYGTKLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-苯基-4,5-二氯-6-哒酮 在 potassium carbonate 作用下， 以 丙酮 、 甲苯 为溶剂， 反应 9.0h， 生成 4-Chloro-5-[4-[[diethoxyphosphoryl-(2-methoxyphenyl)methyl]amino]phenyl]sulfanyl-2-phenylpyridazin-3-one
  参考文献：
  名称：

  Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety

  摘要：

  The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O'-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].

  DOI：

  10.1080/10426507.2010.482543

文献信息

• Synthesis and Antiviral Activities of α-Aminophosphonate Derivatives Containing a Pyridazine Moiety
  作者：Jun Zhou、Hui-Tao Fan、Bao-An Song、Lin-Hong Jin、Pinaki S. Bhadury、De-Yu Hu、Song Yang

  DOI：10.1080/10426507.2010.482543

  日期：2010.12.30

  The title compounds (4) were obtained by the reaction of 2-phenyl-4-chloro-5-(4-amin ophenyl)pyridazin-3(2H)-one, aldehydes, and O,O'-dialkyl phosphite under reflux conditions using dry toluene as a solvent. The preliminary bioassays indicate that the synthesized compounds have moderate to good against tobacco mosaic virus (TMV) activity. It was found that compound 4b had a good inactivation effect in vivo against TMV, with an inhibition rate of 81.0%. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT[image omitted].