N-ethyl-DL-glutamic acid | 881740-08-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethyl-DL-glutamic acid
• 英文别名: N-ethyl-glutamic acid；N-Aethyl-DL-glutaminsaeure；DL-2-Aethylamino-glutarsaeure；inakt.α-Aethylamino-glutarsaeure；N-Aethyl-glutaminsaeure；Aethyl-dl-glutaminsaeure；2-(Ethylamino)pentanedioic acid
• CAS: 881740-08-5
• 化学式: C₇H₁₃NO₄
• 分子量: 175.185
• InChiKey: BIAZEQPYCCADLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-甲氧基羰基顺丁烯二酰亚胺 、 N-ethyl-DL-glutamic acid 在 硫酸 作用下， 以 水 、 碳酸氢钠 为溶剂， 以49%的产率得到N-maleoyl-L-glutamic acid γ-methyl ester
  参考文献：
  名称：

  New conjugates of vinblastine and its derivatives, process for preparing

  摘要：

  描述了吲哚-二氢吲哚型长春碱与蛋白质或蛋白质片段的共轭物，对应于一般公式##STR1##其中R.sub.1表示蛋白质或蛋白质片段；R.sub.2是COO(C.sub.1-3烷基)或CO--R.sub.7，其中R.sub.7是NH.sub.2或氨基酸酯或肽酯；R.sub.3是H、CH.sub.3或CHO；当R.sub.5和R.sub.6单独取时，R.sub.6为H，R.sub.4和R.sub.5中的一个为乙基，另一个为H或OH；当R.sub.5和R.sub.6与它们连接的碳原子一起取时，它们形成一个环氧环，R.sub.4为乙基，A是双功能有机衍生物的残基，该有机衍生物为马来酰氨基酸或马来酰肽或马来酰苯氧基类的衍生物。

  公开号：

  US04828831A1
• 作为产物：
  描述：

  DL-谷氨酸 、 乙醛 在 溶剂黄146 、 铂 作用下， 生成 N-ethyl-DL-glutamic acid 、 N,N-diethyl-DL-glutamic acid
  参考文献：
  名称：

  Kanao, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1946, vol. 66, p. 6

  摘要：

  DOI：

文献信息

• Heterocyclic sulfonamide inhibitors of beta amyloid production
  申请人：ArQule

  公开号：US20020183361A1

  公开（公告）日：2002-12-05

  Compounds of Formula (I), 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described

  提供了符合以下定义的化合物（I）的化合物，其中R1、R2、R3、R4、R5、R6、T、W、X、Y和Z的定义如下，以及其药用盐、水合物和/或前药。描述了使用这些化合物抑制β淀粉样蛋白产生以及治疗阿尔茨海默病和唐氏综合征的方法。
• Catalyst and method for converting low molecular weight paraffinic hydrocarbons into alkenes
  申请人：Bagherzadeh Ebrahim

  公开号：US20060135838A1

  公开（公告）日：2006-06-22

  A process and catalyst for the partial oxidation of low molecular weight paraffinic hydrocarbons, such as methane, ethane, propane, naphtha, and natural gas condensates to form alkenes, such as ethylene, propylene and other valuable by-products. The process involves contacting the low molecular weight paraffinic hydrocarbon with the catalyst in the presence of oxygen or air and optionally steam. The catalyst has a perovskite-type crystalline structure, and lends itself to fixed and fluidized bed reactor configurations. The conversion process is less costly than conventional processes due to low pressure operation, the use of air and steam as a source of oxygen, and lower operating temperatures resulting in less coking, downtime, and reduced cost for materials of construction. Catalyst activity is extended and reactor downtime for catalyst regeneration is minimized by addition of chlorides and/or amines.

  一种用于部分氧化低分子量烷烃烃类碳氢化合物（如甲烷、乙烷、丙烷、石脑油和天然气凝析液）以形成烯烃（如乙烯、丙烯等）和其他有价值的副产品的过程和催化剂。该过程涉及将低分子量烷烃烃类碳氢化合物与催化剂在氧气或空气以及可选的蒸汽存在下接触。催化剂具有钙钛矿型的晶体结构，并适用于固定床和流化床反应器结构。由于低压操作、使用空气和蒸汽作为氧源以及较低的操作温度导致较少的结焦、停机时间和降低建筑材料成本，转化过程比传统工艺成本更低。通过添加氯化物和/或胺，延长了催化剂的活性并将用于催化剂再生的反应器停机时间最小化。
• Phosphoramidate and phosphorothiomidate oligomeric compounds
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US05717083A1

  公开（公告）日：1998-02-10

  Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds and wherein the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidation step or during a coupling step. ##STR1##

  提供具有结构（I）的化合物，其中L基团是骨架段，Y和T基团是用于与感兴趣的靶分子相互作用的功能基团，X基团是氧或硫，E基团是H、共轭基团或在合成化合物过程中使用的中间基团，其中这些化合物是使用H膦酸酯类化学物质制备的，其中在氧化步骤或偶联步骤中添加功能基团。
• COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
  申请人：Evans Conor L.

  公开号：US20160159842A1

  公开（公告）日：2016-06-09

  Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

  本文提供了一种设计和组装非侵入式分析物感应敷料的化合物、系统和方法。该敷料可以具有治疗作用。该敷料包括一个传感器和一个基质。传感器能够检测分子氧、二氧化碳、一氧化氮、血浆中溶解的分析物和氢离子等分析物。基质至少部分对分析物具有渗透性。当传感器在分析物存在的情况下被激发时，该装置会发出可检测的信号。在敷料的一个版本中，传感器包括一种对氧敏感的介质未取代的金属卟啉。当在第一波长照射后激发介质未取代的金属卟啉时，会发出磷光，其强度可用作氧浓度的指示器的第二波长的发射。
• HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION
  申请人：Kreft Anthony F.

  公开号：US20100022594A1

  公开（公告）日：2010-01-28

  Compounds of Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's disease and Down's syndrome are described.

  提供式(I)的化合物，其中R1、R2、R3、R4、R5、R6、T、W、X、Y和Z的定义如本文所述，以及其药学上可接受的盐、水合物和/或前药。描述了使用这些化合物抑制β淀粉样蛋白产生和治疗阿尔茨海默病和唐氏综合症的方法。