N-morpholin-4-ylmethyl-acetamide | 72721-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-morpholin-4-ylmethyl-acetamide
• 英文别名: N-(morpholin-4-ylmethyl)acetamide
• CAS: 72721-55-2
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: BNVGEMUDEPATDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰胺 、 双吗啉甲烷 在 溶剂黄146 作用下， 生成 N-morpholin-4-ylmethyl-acetamide
  参考文献：
  名称：

  Le Floc'h,Y. et al., Bulletin de la Societe Chimique de France, 1979, vol. , p. 409 - 414

  摘要：

  DOI：

文献信息

• FLOCH Y. LE; PLUSQUELLEC D.; SOYER N.; KERFANTO M., BULL. SOC. CHIM. FRANCE, PART 2, 1979, NO 7-8, 409-414
  作者：FLOCH Y. LE、 PLUSQUELLEC D.、 SOYER N.、 KERFANTO M.

  DOI：——

  日期：——
• 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
  申请人：Andrés-Gil José Ignacio

  公开号：US20140147386A1

  公开（公告）日：2014-05-29

  The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extent of phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, or disorders in which both PDE2 and PDE 10 are involved, such as neurological and psychiatric disorders, and endocrinological or metabolic diseases. The present invention also relates to radiolabelled compounds which may be useful for imaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.
• ANTIMICROBIAL AGENTS
  申请人：Rutgers, the State University of New Jersey

  公开号：US20150031694A1

  公开（公告）日：2015-01-29

  The invention provides compounds of formula (I): wherein R 1 -R 7 and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
• US9475783B2
  申请人：——

  公开号：US9475783B2

  公开（公告）日：2016-10-25
• [EN] ANTIBIOTIC COMPOUNDS<br/>[FR] COMPOSÉS ANTIBIOTIQUES
  申请人：MERCK & CO INC

  公开号：WO2007127200A2

  公开（公告）日：2007-11-08

  [EN] The present invention relates to novel carboxylic acid derivatives of thiazolyl peptide antibiotics capable of treating serious bacterial infections in mammals, and particularly, in humans. These carboxylic acid analogs can also be versatile intermediates for the preparation of new derivatives with useful antibacterial activity.
  [FR] L'invention concerne de nouveaux dérivés d'acide carboxylique d'antibiotiques à base de peptides de thiazolyle qui permettent de traiter des infections bactériennes graves chez des mammifères, et en particulier chez l'être humain. Ces analogues d'acide carboxylique peuvent aussi constituer des produits intermédiaires polyvalents destinés à la préparation de nouveaux dérivés possédant une activité antibactérienne utile.