Cyclopentyl(3-pyridyl)keton | 82465-75-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclopentyl(3-pyridyl)keton
• 英文别名: Cyclopentyl-(3-pyridyl)-methanon；cyclopentyl(pyridin-3-yl)methanone
• CAS: 82465-75-6
• 化学式: C₁₁H₁₃NO
• 分子量: 175.23
• InChiKey: HRVCQBYLXUYLBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cyclopentyl(3-pyridyl)keton 生成 4,6,7-trimethyl-3-pyridin-3-ylspiro[3H-1-benzofuran-2,1'-cyclopentane]-5-ol
  参考文献：
  名称：

  TERAO, SHINJI;MAKI, YOSHITAKA

  摘要：

  DOI：
• 作为产物：
  描述：

  环戊基(2-甲基-1-氮丙啶基)甲酮 生成 Cyclopentyl(3-pyridyl)keton
  参考文献：
  名称：

  TERAO, SHINJI;MAKI, YOSHITAKA

  摘要：

  DOI：

文献信息

• C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow
  作者：Paul Dingwall、Andreas Greb、Lorène N. S. Crespin、Ricardo Labes、Biagia Musio、Jian-Siang Poh、Patrick Pasau、David C. Blakemore、Steven V. Ley

  DOI：10.1039/c8cc06202a

  日期：——

  Here we explore further the use of oxadiazolines, non-stabilised diazo precursors which are bench stable, in direct, non-catalytic, aldehyde C–H functionalisation reactions under UV photolysis in flow and free from additives.

  这里我们进一步探讨了在UV光解条件下，在流动状态下且无需添加剂的情况下，使用氧代唑啉（oxadiazolines）这种非稳定的重氮前体进行醛的C-H官能化反应。
• Double Duty for Cyanogen Bromide in a Cascade Synthesis of Cyanoepoxides
  作者：Zhou Li、Vladimir Gevorgyan

  DOI：10.1002/anie.201006966

  日期：2011.3.14

  An unprecedented reaction mode of cyanogen bromide has been discovered. Under basic conditions, cyanogen bromide acts as an equivalent of both Br+ and CN− to convert enolizable ketones into the corresponding cyanoepoxides in good yields. This unique reaction mode provides new, one‐pot access to densely substituted cyanoepoxides from easily available ketones (see scheme).

  已经发现了前所未有的溴化氰反应模式。在碱性条件下，溴化氰同时充当Br中的等效+和CN -至烯醇化的酮转化成良好产率的相应cyanoepoxides。这种独特的反应模式为从容易获得的酮类中稠密取代的氰基环氧化物提供了新的一锅通（见方案）。
• QUININE COMPOUNDS, AND OPTICAL ISOMERS, PREPARATION METHOD AND MEDICAL USE THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO., LTD

  公开号：US20160244439A1

  公开（公告）日：2016-08-25

  The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of M 1 and M 3 , but have no significant effect on M 2 receptor subtype, and the above compounds are characterized by rapid action, long-lasting efficacy, and low toxic and side-effects when used to treat rhinitis, post-cold rhinitis, chronic trachitis, airway hyperresponsiveness, asthma, chronic obstructive pulmonary diseases, cough, urinary incontinence, frequent urination, unstable bladder syndrome, bladder spasms, bladder inflammation and gastrointestinal diseases such as irritable bowel syndrome, spastic colitis, as well as duodenal and gastric ulcers.

  本发明揭示了一类奎宁化合物及其药学上可接受的盐、溶剂化物、前药或其光学异构体。本发明还揭示了上述化合物对M1和M3受体亚型具有选择性拮抗作用，但对M2受体亚型没有显著影响，上述化合物具有快速作用、持久疗效和低毒性和副作用的特点，用于治疗鼻炎、感冒后鼻炎、慢性气管炎、气道过度反应、哮喘、慢性阻塞性肺疾病、咳嗽、尿失禁、频尿、不稳定膀胱综合征、膀胱痉挛、膀胱炎和肠胃疾病，如肠易激综合征、痉挛性结肠炎、以及十二指肠和胃溃疡。
• Mesoionic Carbene‐Catalyzed Formyl Alkylation of Aldehydes
  作者：Chang Liu、Zengyu Zhang、Liang‐Liang Zhao、Guy Bertrand、Xiaoyu Yan

  DOI：10.1002/anie.202303478

  日期：2023.6.12

  A metal-free protocol for the coupling reaction of aldehydes and alkyl halides was successfully developed with mesoionic carbenes (MICs) as catalysts. This versatile strategy delivers a large diversity of simple ketones as well as bio-active molecules by late-stage functionalization.

  以中离子卡宾 (MIC) 为催化剂，成功开发了一种用于醛和烷基卤化物偶联反应的无金属方案。这种多功能的策略通过后期功能化提供了多种多样的简单酮和生物活性分子。
• Coumaran derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0273647A1

  公开（公告）日：1988-07-06

  A compound of the formula wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are combined to form a butadienylene group which may optionally be substituted, R3 and R4 are hydrogen or alkyl groups which may 'optionally be substituted or wherein R3 and R4 are combined to form a polymethylene group, and R5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

  式中 R 为低级烷基，R0 为氢或酰基，R1 和 R2 为可选择被取代的低级烷基，或其中 R1 和 R2 结合形成可选择被取代的丁二烯基，R3 和 R4 为氢或可'选择被取代的烷基，或其中 R3 和 R4 结合形成聚亚甲基，R5 为可选择被取代的低级烷基、芳香族或杂环基，或其药学上可接受的盐的化合物，具有改善心血管系统和抗过敏作用，可用作药物，如抗肿瘤药、抗过敏药等。