1-羟基-1,3-二苯基-丙酮缩氨基脲 | 107059-94-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 1-羟基-1,3-二苯基-丙酮缩氨基脲
• 英文名称: 1-hydroxy-1,3-diphenyl-acetone semicarbazone
• 英文别名: 1-Hydroxy-1,3-diphenyl-aceton-semicarbazon
• CAS: 107059-94-9
• 化学式: C₁₆H₁₇N₃O₂
• 分子量: 283.33
• InChiKey: TUUBDHIEUGCMSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.71
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-benzyl-2-hydroxy-3-oxo-3-phenyl-propionic acid 在 sodium carbonate 作用下， 生成 1-羟基-1,3-二苯基-丙酮缩氨基脲
  参考文献：
  名称：

  Jarrousse, Annales de Chimie (Cachan, France), 1938, vol. <11> 9, p. 157,207, 215

  摘要：

  DOI：

文献信息

• 121. αβ-Diphenylpropaldehyde
  作者：Harold Burton、C. W. Shoppee

  DOI：10.1039/jr9370000546

  日期：——
• Effect of phenobarbitone on the low-dose dexamethasone suppression test and the urinary corticoid: creatinine ratio in dogs
  作者：SF FOSTER、DB CHURCH、ADJ WATSON

  DOI：10.1111/j.1751-0813.2000.tb10349.x

  日期：2000.1

  ObjectivesTo investigate potential effects of phenobarbitone on the low‐dose dexamethasone suppression (LDDS) test and urinary corticoid to creatinine ratio in dogs in a controlled prospective study and in a clinical setting.AnimalsTen crossbreed experimental dogs and 10 client‐owned dogs of mixed breeds treated chronically with phenobarbitone to control seizures.ProceduresExperimental dogs were allocated to treatment (6 mg/kg oral phenobarbitone, n = 6) and control (n = 4) groups. LDDS tests (dexamethasone 0.01 mg/kg intravenously, cortisol concentration determined at 0, 2, 4, 6 and 8 h) were conducted repeatedly over a 3‐month period. Urinary corticoid to creatinine ratios were measured before LDDS tests. A single LDDS test was performed on 10 epileptic dogs.ResultsLDDS and urinary corticoid to creatinine ratios in dogs were not affected by treatment with phenobarbitone.ConclusionsPhenobarbitone does not interfere with LDDS testing regardless of dosage or treatment time. Urinary corticoid to creatinine ratios are also unaffected.