methyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate | 207863-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate
• 英文别名: N-tert-Butoxycarbonyl-α-(diethoxyphosphoryl)glycine methyl ester；N-Boc-2-(diethoxyphosphoryl)glycinate；methyl 2-(tert-butoxycarbonylamino)-2-(diethoxyphosphinooxy)acetate；Methyl 2-((tert-butoxycarbonyl)amino)-2-(diethoxyphosphoryl)acetate；methyl 2-diethoxyphosphoryl-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS: 207863-56-7
• 化学式: C₁₂H₂₄NO₇P
• mdl: MFCD00971612
• 分子量: 325.299
• InChiKey: KDUJLBSDSOIILX-UHFFFAOYSA-N

物化性质

• 沸点：
  424.5±40.0 °C(Predicted)
• 密度：
  1.163±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate 在 4-二甲氨基吡啶 、 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 benzyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate
  参考文献：
  名称：

  C-Linked Galactosyl Serine AFGP Analogues as Potent Recrystallization Inhibitors

  摘要：

  A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications.

  DOI：

  10.1021/ol050677x
• 作为产物：
  描述：

  N-CBZ-(二乙氧基磷酸基)氨基酸甲酯 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 methyl 2-(tert-butyloxycarbonylamino)-2-(diethyloxyphosphoryl)acetate
  参考文献：
  名称：

  C-Linked Galactosyl Serine AFGP Analogues as Potent Recrystallization Inhibitors

  摘要：

  A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications.

  DOI：

  10.1021/ol050677x

文献信息

• [EN] FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE<br/>[FR] THIAZOLES SUBSTITUÉS PAR FLUOROISOQUINOLÉINE ET LEURS MÉTHODES D'APPLICATION
  申请人：AMGEN INC

  公开号：WO2010083246A1

  公开（公告）日：2010-07-22

  The invention relates to thiazole compounds of Formula (I) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

  该发明涉及式(I)的噻唑化合物及其组合物，用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有此处提供的定义。该发明还涉及在治疗与异常细胞生长、癌症、炎症和代谢紊乱相关的疾病状态中使用这种噻唑化合物和其组合物的治疗用途。
• Deconjugation of Dehydroamino Acids:  Stereoselective Synthesis of Racemic (<i>E</i>)-Vinylglycines
  作者：Paul A. Alexander、Stephen P. Marsden、Dulce M. Muñoz Subtil、John C. Reader

  DOI：10.1021/ol052139q

  日期：2005.11.1

  [reaction: see text] A practical and general two-step synthesis of carbamate-protected (E)-vinylglycines from aliphatic aldehydes is reported. The key step involves the kinetic alpha-protonation of dianionic dienolates derived from dehydroamino acids.

  [反应：见正文]据报道，从脂肪族醛中合成氨基甲酸酯保护的（E）-乙烯基甘氨酸的实用且通用的两步过程。关键步骤涉及衍生自脱氢氨基酸的二阴离子二烯酸酯的动力学α-质子化。
• [EN] N1-PHENYLPROPANE-1,2-DIAMINE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS<br/>[FR] COMPOSÉS DE N1-PHÉNYLPROPANE-1,2-DIAMINE AYANT UNE ACTIVITÉ SÉLECTIVE DANS DES CANAUX SODIQUES SENSIBLES À LA TENSION
  申请人：MERCK SHARP & DOHME

  公开号：WO2017165204A1

  公开（公告）日：2017-09-28

  Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-l or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.

  公开了化合物A-1的结构，或其盐：化合物A-1的结构如下，其中J、K、Q和R1的定义如本文所述，这些化合物具有抑制外周和交感神经元中发现的钠离子通道的特性。还描述了包含化合物A-1或其盐的药物配方，并使用这些化合物治疗疼痛（例如慢性疼痛）、咳嗽或瘙痒症状的方法。
• Enantioselective hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives
  作者：Feng Wan、Nan Wang、Yuxin Zhu、Chuyan Tang、Jerome Claverie、Wenjun Tang

  DOI：10.1039/d1cc01277k

  日期：——

  An efficient asymmetric hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives has been achieved with a Rh-ArcPhos catalyst, affording a series of α-acylamino-β-alkyl tetrahydropyranones with two contiguous chiral centers in up to 96% ee and 1000 TON.

  使用 Rh-ArcPhos 催化剂实现了环状四取代烯烃脱氢氨基酸衍生物的有效不对称氢化，得到了一系列具有两个连续手性中心的 α-酰基氨基-β-烷基四氢吡喃酮，其 ee 和 1000 TON。
• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SPINIFEX PHARM PTY LTD

  公开号：WO2015003223A1

  公开（公告）日：2015-01-15

  The present invention relates generally to compounds that are useful in antagonizing the angiotensin II type 2 (AT2) receptor. More particularly, the invention relates to substituted isoquinoline compounds and their use as AT2 receptor antagonists. Pharmaceutical compositions comprising the compounds and their use in modulating the AT2 receptor and therapies that require modulation of the AT2 receptor are described.

  本发明一般涉及对抗血管紧张素II型2（AT2）受体的化合物。更具体地，本发明涉及取代异喹啉化合物及其用作AT2受体拮抗剂的用途。描述了包含这些化合物的药物组合物以及它们在调节AT2受体和需要调节AT2受体的治疗中的用途。

表征谱图