1-(6-bromohexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione | 1333514-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(6-bromohexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione
• 英文别名: 1-(6-Bromohexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-5-methyl-spiro[indoline-3,2'-thiazolidine]-2,4'-dione；1'-(6-bromohexyl)-3-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-5'-methylspiro[1,3-thiazolidine-2,3'-indole]-2',4-dione
• CAS: 1333514-55-8
• 化学式: C₂₈H₃₁BrN₄O₃S
• 分子量: 583.549
• InChiKey: OYVFUDMYJDYAQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(6-bromohexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione 在 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 1-(6-(3',5'-dimethyl-2-oxo-1',7'-diphenyl-1',7'-dihydrospiro[indoline-3,4'-pyrano[2,3-c:6,5-c']dipyrazol]-1-yl)hexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione
  参考文献：
  名称：

  Design and synthesis of spiro[indole-thiazolidine]spiro[indole-pyrans] as antimicrobial agents

  摘要：

  A series of novel spiro[indole-thiazolidine]spiro[indole-pyran] derivatives were synthesized from N-(bromoalkyl)indol-2,3-diones via monospiro-bisindole intermediates; the two indole nuclei being connected via N-(CH2)(n)-N linker. Synthesized compounds were evaluated for their antimicrobial activities in vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Staphylococcus epidermis), four Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumonia) as well as four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, and Candida albicans) using Cup plate method. Bis spiro-indoles exhibited stronger antibacterial and antifungal efficiency than their corresponding mono spiro-indoles. Compound 10e, the most active derivative was shown to inhibit the growth of all bacterial strains and two fungal strains (A. niger and C. albicans) (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.121
• 作为产物：
  描述：

  1-(6-bromohexyl)-5-methylindoline-2,3-dione 以 乙醇 、 甲苯 为溶剂， 反应 11.0h， 生成 1-(6-bromohexyl)-3'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-5-methylspiro[indoline-3,2'-thiazolidine]-2,4'-dione
  参考文献：
  名称：

  Design and synthesis of spiro[indole-thiazolidine]spiro[indole-pyrans] as antimicrobial agents

  摘要：

  A series of novel spiro[indole-thiazolidine]spiro[indole-pyran] derivatives were synthesized from N-(bromoalkyl)indol-2,3-diones via monospiro-bisindole intermediates; the two indole nuclei being connected via N-(CH2)(n)-N linker. Synthesized compounds were evaluated for their antimicrobial activities in vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Staphylococcus epidermis), four Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumonia) as well as four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, and Candida albicans) using Cup plate method. Bis spiro-indoles exhibited stronger antibacterial and antifungal efficiency than their corresponding mono spiro-indoles. Compound 10e, the most active derivative was shown to inhibit the growth of all bacterial strains and two fungal strains (A. niger and C. albicans) (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.121