cis-3-Hydroxycyclohex-4-en-1-carbonsaeure | 1932168-86-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-3-Hydroxycyclohex-4-en-1-carbonsaeure
• 英文别名: cis-5-Hydroxycyclohex-3-enecarboxylic acid；(1R,5R)-5-hydroxycyclohex-3-ene-1-carboxylic acid
• CAS: 1932168-86-9
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: CNPPQIVHKLYCGG-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-3-Hydroxycyclohex-4-en-1-carbonsaeure 在 mercury(II) diacetate 作用下， 生成
  参考文献：
  名称：

  Synthetic study of (+-)-canadensolide and related dilactones. Double lactonization of unsaturated dicarboxylic acids via acyl hypoiodite intermediates

  摘要：

  DOI：

  10.1021/jo00901a014
• 作为产物：
  描述：

  6-oxabicyclo<3.2.1>-oct-3-en-7-one 在 sodium hydroxide 作用下， 生成 cis-3-Hydroxycyclohex-4-en-1-carbonsaeure
  参考文献：
  名称：

  Synthetic study of (+-)-canadensolide and related dilactones. Double lactonization of unsaturated dicarboxylic acids via acyl hypoiodite intermediates

  摘要：

  DOI：

  10.1021/jo00901a014

文献信息

• METHOD FOR THE PREPARATION OF ENANTIOMER FORMS OF CIS-CONFIGURED 3-HYDROXYCYCLOHEXANE CARBOXYLIC ACID DERIVATIVES USING HYDROLASES
  申请人：Holla Wolfgang

  公开号：US20070197788A1

  公开（公告）日：2007-08-23

  The present invention relates to a process for preparing chiral non-racemic cis-configured cyclohexanols or cyclohexanol derivatives of the formula (I) Cis-configured hydroxyl-cyclohexane carboxylic acid derivatives of formula (I) are central building blocks or immediate precursors for the medicinally active compounds which allow a therapeutic modulation of the lipid and/or carbohydrate metabolism and are thus suitable for preventing and/or treating type II diabetes, hyperglycemia and artherosclerosis. The cis-configured hydroxyl-cyclohexane carboxylic acid derivatives of formula (I) are central building blocks or immediate precursors for the medicinally active compounds described in the prior art.

  本发明涉及一种制备手性非外消旋顺式环己醇或环己醇衍生物的过程，其化学式为(I)。化学式(I)的顺式羟基环己烷羧酸衍生物是中心构建块或药物活性化合物的直接前体，可用于治疗脂质和/或碳水化合物代谢，因此适用于预防和/或治疗II型糖尿病、高血糖和动脉硬化。化学式(I)的顺式羟基环己烷羧酸衍生物是先前技术中描述的药物活性化合物的中心构建块或直接前体。
• Production Of Polyketides And Other Natural Products
  申请人：Gregory Matthew Alan

  公开号：US20090253732A1

  公开（公告）日：2009-10-08

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及聚酮类化合物和其他天然产物的生产，以及化合物库和独特新化合物的制备。因此，本发明提供了17-去甲基拉帕霉素及其类似物，包括重组菌株的制备方法，以及本发明化合物的分离和用途。此外，本发明还提供了将17-去甲基拉帕霉素及其类似物用于诱导或维持免疫抑制、促进神经再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥、移植物抗宿主病、自身免疫性疾病、炎症性血管疾病和纤维化疾病的调节。
• 17-Desmethylrapamycin and analogues thereof, methods for their production and their use as immunosupressants, anticancer agents, antifungal agents etc.
  申请人：Biotica Technology Limited

  公开号：EP2471797A2

  公开（公告）日：2012-07-04

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及多酮类化合物和其他天然产物的生产，以及化合物库和单个新型化合物。因此，在一个方面，本发明提供了 17-去甲基拉帕霉素及其类似物、其生产方法（包括重组菌株）以及本发明化合物的分离和用途。在另一个方面，本发明提供了17-去甲基拉帕霉素及其类似物在诱导或维持免疫抑制、刺激神经元再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥反应、移植物对宿主疾病、自身免疫性疾病、炎症性血管疾病和纤维化疾病以及调节伤口愈合中的用途。
• Wardrop, Duncan J.; Bowen, Edward G.; Forslund, Raymond E., Journal of the American Chemical Society, 2010, vol. 132, p. 1188 - 1189
  作者：Wardrop, Duncan J.、Bowen, Edward G.、Forslund, Raymond E.、Sussman, Adam D.、Weerasekera, Samanthi L.

  DOI：——

  日期：——
• 17-DESMETHYLRAPAMYCIN AND ANALOGUES THEREOF, METHODS FOR THEIR PRODUCTION AND THEIR USE AS IMMUNOSUPRESSANTS, ANTICANCER AGENTS, ANTIFUNGAL AGENTS ETC.
  申请人：Buck Institute for Research on Aging

  公开号：EP2471797B1

  公开（公告）日：2016-02-03