1-(2,3-Dihydro-1H-indole-5-sulfonyl)-4-(thiophen-2-yl)imidazolidin-2-one | 823786-82-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(2,3-Dihydro-1H-indole-5-sulfonyl)-4-(thiophen-2-yl)imidazolidin-2-one
• 英文别名: 1-(2,3-dihydro-1H-indol-5-ylsulfonyl)-4-thiophen-2-ylimidazolidin-2-one
• CAS: 823786-82-9
• 化学式: C₁₅H₁₅N₃O₃S₂
• 分子量: 349.434
• InChiKey: DJGIWWGFDMUSJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(2,3-Dihydro-1H-indole-5-sulfonyl)-4-(thiophen-2-yl)imidazolidin-2-one 在 吡啶 、 镍 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 1-[1-(4-Amino-benzoyl)-2,3-dihydro-1H-indole-5-sulfonyl]-4-thiophen-2-yl-imidazolidin-2-one
  参考文献：
  名称：

  Novel diarylsulfonylurea derivatives as potent antimitotic agents

  摘要：

  A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.069
• 作为产物：
  描述：

  (9ci)-2,3-二氢-1-(三氟乙酰基)-1H-吲哚 在 氯磺酸 、 sodium hydroxide 、 氨 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 1-(2,3-Dihydro-1H-indole-5-sulfonyl)-4-(thiophen-2-yl)imidazolidin-2-one
  参考文献：
  名称：

  Novel diarylsulfonylurea derivatives as potent antimitotic agents

  摘要：

  A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.069

文献信息

• Novel diarylsulfonylurea derivatives as potent antimitotic agents
  作者：Semi Kim、Ji Hyun Park、Sun-Young Koo、Jung In Kim、Min-Hyeung Kim、Ji Eun Kim、Kiwon Jo、Hwan Geun Choi、Sung Bae Lee、Sang-Hun Jung

  DOI：10.1016/j.bmcl.2004.09.069

  日期：2004.12

  A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.