5-吲哚-1-基戊酸 | 143217-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-吲哚-1-基戊酸
• 英文名称: 5-(Indol-1-yl)pentanoic acid
• 英文别名: 1H-Indole-1-pentanoic acid；5-indol-1-ylpentanoic acid
• CAS: 143217-45-2
• 化学式: C₁₃H₁₅NO₂
• 分子量: 217.268
• InChiKey: KTVCYQXZXQUSRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-吲哚-1-基戊酸 在 sodium hydrazide 、 磷酸单乙基酯 、 氨 作用下， 生成 Diethyl 3-(4-indol-1-ylbutyl)-1,2,4-triazine-5,6-dicarboxylate
  参考文献：
  名称：

  Indole as a dienophile in inverse electron demand Diels-Alder reactions. 3. Intramolecular reactions with 1,2,4-triazines to access the canthine skeleton

  摘要：

  The intramolecular inverse electron demand cycloaddition of indole with 1,2,4-triazines connected by a tri- or tetramethylene tether linking the indole N-1 position with the triazinyl 3-position successfully produces the canthine skeleton and the homologous system with a seven-membered D-ring.

  DOI：

  10.1021/jo00046a005
• 作为产物：
  描述：

  delta-戊内酯 、 吲哚 在 potassium hydride 作用下， 生成 5-吲哚-1-基戊酸
  参考文献：
  名称：

  Indole as a dienophile in inverse electron demand Diels-Alder reactions. 3. Intramolecular reactions with 1,2,4-triazines to access the canthine skeleton

  摘要：

  The intramolecular inverse electron demand cycloaddition of indole with 1,2,4-triazines connected by a tri- or tetramethylene tether linking the indole N-1 position with the triazinyl 3-position successfully produces the canthine skeleton and the homologous system with a seven-membered D-ring.

  DOI：

  10.1021/jo00046a005

文献信息

• Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
  申请人：Schering Corporation

  公开号：EP1541175A2

  公开（公告）日：2005-06-15

  The present invention provides compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor and (b) at least one cardiovascular agent different from the sterol absorption inhibitor, which can be useful for treating vascular conditions, obesity, diabetes and lowering plasma levels of sterols.

  本发明提供的组合物、治疗组合物和方法包括：(a) 至少一种固醇吸收抑制剂和 (b) 至少一种不同于固醇吸收抑制剂的心血管药剂，它们可用于治疗血管疾病、肥胖症、糖尿病和降低血浆中的固醇水平。
• Intramolecular Cycloaddition of Isomunchnone Dipoles to Heteroaromatic .pi.-Systems
  作者：Albert Padwa、Donald L. Hertzog、William R. Nadler

  DOI：10.1021/jo00102a037

  日期：1994.11

  A series of furanyl-, thienyl-, and indole-substituted diazo imides were prepared by treating the appropriate amides with diketene to give the N-acetoacylated imides. Exposure of the imides to standard diazo transfer conditions afforded the desired diazo imides. Treatment of these diazo imides bearing tethered heterocyclic rings with rhodium(II) acetate affords transient isomunchnone dipoles. The mesoionic dipoles are formed by cyclization of the rhodium carbenoid onto the neighboring amide carbonyl oxygen atom. The scope and limitations of the intramolecular 1,3-dipolar cycloaddition of the isomunchnones across a tethered furan and thiophene ring were studied. The facility of the internal cycloaddition is influenced by the length and nature of the tether connecting the dipole and dipolarophile functionalities. The reaction is critically dependent on conformational factors in the transition state. In addition, the first examples of intramolecular cycloaddition of isomunchnones to indole dipolarophiles are reported. Cycloadditions of this type generate highly functionalized polyheterocyclic systems with complete relative stereocontrol at the newly formed stereocenters.
• COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH CARDIOVASCULAR AGENT(S) FOR THE TREATMENT OF VASCULAR CONDITIONS
  申请人：SCHERING CORPORATION

  公开号：EP1385548B1

  公开（公告）日：2007-05-23
• ANTI-PCSK9 AND METHODS FOR TREATING LIPID AND CHOLESTEROL DISORDERS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2205639B1

  公开（公告）日：2015-12-23
• EGF-A DOMAIN-MEDIATED MODULATION OF PCKS9 FOR TREATING LIPID DISORDERS
  申请人：Zhang Qing

  公开号：US20110150875A1

  公开（公告）日：2011-06-23

  The present invention provides, in part, methods and compositions for treating lipid disorders comprising administering a polypeptide that inhibits PCSK9. A novel method for identifying polypeptides that interact with PCSK9 is also provided.