7-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-heptanoic acid | 65351-70-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-heptanoic acid
• 英文别名: 7-(Tetrahydropyran-2-yloxy)heptanoic acid；7-(oxan-2-yloxy)heptanoic acid
• CAS: 65351-70-4
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: GWEHENJAQLUXDL-UHFFFAOYSA-N

物化性质

• 沸点：
  373.3±37.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-heptanoic acid 在 盐酸羟胺 、 sodium ethanolate 、 sodium acetate 、 iron(II) sulfate 、 三乙胺 、 sodium iodide 、 lithium diisopropyl amide 、 sodium nitrite 作用下， 以 乙醚 、 乙醇 、 溶剂黄146 为溶剂， 反应 29.83h， 生成
  参考文献：
  名称：

  Synthesis and olfactory properties of regioisomeric alkynolides and (Z)-alkenolides

  摘要：

  A general approach to the title compounds (Z)-9a-d via 8a-d from easily available starting materials is presented. The olfactory properties of these macrolides are discussed. A new synthesis of the precursor 7e of(Z)-ambrettolide (1) is also described. (C) 1999 Elsevier Science Ltd. AII rights reserved.

  DOI：

  10.1016/s0040-4020(99)00041-1
• 作为产物：
  描述：

  2-(7-硝基庚氧基)四氢吡喃 在 溶剂黄146 、 sodium nitrite 作用下， 以 二甲基亚砜 为溶剂， 以90%的产率得到7-(tetrahydro-2'H-pyran-2'-yl-oxy)-1-heptanoic acid
  参考文献：
  名称：

  伯硝基烷和伯烷基溴向相应的羧酸的新型转化。

  摘要：

  DOI：

  10.1021/jo962110n

文献信息

• MIMICS OF ACYL COENZYME-A, COMPOSITIONS THEREOF, AND METHODS OF CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Esperion Therapeutics Inc.

  公开号：EP1497247A2

  公开（公告）日：2005-01-19
• [EN] FUNCTIONALIZED LONG CHAIN DERIVATIVES AS ACYL COENZYME-A MIMICS, COMPOSITIONS THEREOF, AND METHODS OF CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] DERIVES FONCTIONNALISES A CHAINE LONGUE UTILISES COMME MIMIQUES D'ACYL-COENZYME A ET LEURS COMPOSITIONS, METHODES DE REGULATION DU TAUX DE CHOLESTEROL ET UTILISATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2003087108A2

  公开（公告）日：2003-10-23

  The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
• Novel Transformation of Primary Nitroalkanes and Primary Alkyl Bromides to the Corresponding Carboxylic Acids
  作者：Christophe Matt、Alain Wagner、Charles Mioskowski

  DOI：10.1021/jo962110n

  日期：1997.1.1
• Synthesis and olfactory properties of regioisomeric alkynolides and (Z)-alkenolides
  作者：Jürgen Lehmann、Werner Tochtermann

  DOI：10.1016/s0040-4020(99)00041-1

  日期：1999.2

  A general approach to the title compounds (Z)-9a-d via 8a-d from easily available starting materials is presented. The olfactory properties of these macrolides are discussed. A new synthesis of the precursor 7e of(Z)-ambrettolide (1) is also described. (C) 1999 Elsevier Science Ltd. AII rights reserved.