Cyclohexanebutanal, 1-methyl-3-oxo- | 1824142-82-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclohexanebutanal, 1-methyl-3-oxo-
• 英文别名: 4-(1-methyl-3-oxocyclohexyl)butanal
• CAS: 1824142-82-6
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: LZRZHTTYWVYPMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Cyclohexanebutanal, 1-methyl-3-oxo- 在 TSA 作用下， 以 苯 为溶剂， 以78%的产率得到3,4,4a,5,6,7-hexahydro-4a-methyl-1(2H)-naphthalenone
  参考文献：
  名称：

  Efficient One-Step Conversion of Primary Aliphatic Amines into Primary Alcohols:  Application to a Model Study for the Total Synthesis of (±)-Scopadulin

  摘要：

  Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.[Graphics]

  DOI：

  10.1021/ol006334a
• 作为产物：
  描述：

  3-methyl-3-<3-(1,3-dioxolan-2-yl)propyl>cyclohexanone 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 Cyclohexanebutanal, 1-methyl-3-oxo-
  参考文献：
  名称：

  Efficient One-Step Conversion of Primary Aliphatic Amines into Primary Alcohols:  Application to a Model Study for the Total Synthesis of (±)-Scopadulin

  摘要：

  Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.[Graphics]

  DOI：

  10.1021/ol006334a

文献信息

• CATALYSTS, LIGANDS AND USE THEREOF
  申请人：FLETCHER Stephen Patrick

  公开号：US20160074852A1

  公开（公告）日：2016-03-17

  According to the present invention, there is provided a catalytic complex comprising a metal, one or more ligands and one or more counterions, wherein said one or more ligands include a non-racemic chiral ligand and wherein said one or more counterions include a triflimide counterion. Also provided are methods of making said catalytic complex and processes for producing chiral compounds which involve the use of said catalytic complex. In addition, the present invention provides compounds of the formula (2) as defined herein. The compounds of formula (2) may be useful as ligands in catalytic complexes.

  根据本发明，提供了一种催化复合物，包括一种金属，一个或多个配体和一个或多个对离子，其中所述的一个或多个配体包括非对映手性配体，所述的一个或多个对离子包括三氟甲烷磺酰亚胺对离子。还提供了制备所述催化复合物的方法和利用所述催化复合物生产手性化合物的方法。此外，本发明提供了如下所定义的化合物（2）。化合物（2）可以作为催化复合物中的配体有用。
• US9636670B2
  申请人：——

  公开号：US9636670B2

  公开（公告）日：2017-05-02
• [EN] CATALYSTS, LIGANDS AND USE THEREOF<br/>[FR] CATALYSEURS, LIGANDS ET UTILISATION ASSOCIÉE
  申请人：ISIS INNOVATION

  公开号：WO2014170642A2

  公开（公告）日：2014-10-23

  According to the present invention, there is provided a catalytic complex comprising a metal, one or more ligands and one or more counterions, wherein said one or more ligands include a non-racemic chiral ligand and wherein said one or more counterions include a triflimide counterion. Also provided are methods of making said catalytic complex and processes for producing chiral compounds which involve the use of said catalytic complex. In addition, the present invention provides compounds of the formula (2) as defined herein. The compounds of formula (2) may be useful as ligands in catalytic complexes.