2-Amino-5-<1-(benzotriazol-1-yl)propyl>-3-methylpyridine | 173960-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-Amino-5-<1-(benzotriazol-1-yl)propyl>-3-methylpyridine
• 英文别名: 5-[1-(Benzotriazol-1-yl)propyl]-3-methylpyridin-2-amine
• CAS: 173960-27-5
• 化学式: C₁₅H₁₇N₅
• 分子量: 267.333
• InChiKey: JPEWBAZZRLWZFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴丁基-镁 、 2-Amino-5-<1-(benzotriazol-1-yl)propyl>-3-methylpyridine 以 四氢呋喃 为溶剂， 反应 8.0h， 以65%的产率得到2-Amino-5-(2-ethylpentyl)-3-methylpyridine
  参考文献：
  名称：

  Katritzky, Alan R.; El-Zemity, Saad; Lang, Hengyuan, Journal of the Chemical Society. Perkin transactions I, 1995, # 24, p. 3129 - 3134

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-3-甲基吡啶 在 对甲苯磺酸 正丁基锂 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 72.25h， 生成 2-Amino-5-<1-(benzotriazol-1-yl)propyl>-3-methylpyridine
  参考文献：
  名称：

  Synthesis and structure-activity relationships for anticipated molluscicidal activity of some 2-amino-5-substituted pyridine derivatives

  摘要：

  A series of 2-amino-5-substituted pyridine derivatives was synthesized and their molluscicidal activity against white garden, Theba pisana (Muller), and brown garden, Helix aspersa (Muller), snails was investigated by two methods of application. Some of these compounds showed strong activity under laboratory conditions against the two types of snail. T pisana was more sensitive to the tested compounds than H aspersa. The most effective compounds were 2-amino-5-(benzotriazole-1-ylmethyl)-3-methylpyridine, 2-amino-5-[1-(benzotriazole-1-yl)nonyl]-3-methylpyridine and 2-[(1,2,4-triazole-1-ylmethyl) amino]-3-methylpyridine which exhibited high molluscicidal activity. The toxicity results are discussed in relation to the chemical structures. (C) 1999 Society of Chemical Industry.

  DOI：

  10.1002/(sici)1096-9063(199912)55:12<1203::aid-ps82>3.0.co;2-9

文献信息

• Katritzky, Alan R.; El-Zemity, Saad; Lang, Hengyuan, Journal of the Chemical Society. Perkin transactions I, 1995, # 24, p. 3129 - 3134
  作者：Katritzky, Alan R.、El-Zemity, Saad、Lang, Hengyuan

  DOI：——

  日期：——
• Synthesis and structure-activity relationships for anticipated molluscicidal activity of some 2-amino-5-substituted pyridine derivatives
  作者：Saad R El-Zemity、Mohamed A Radwan

  DOI：10.1002/(sici)1096-9063(199912)55:12<1203::aid-ps82>3.0.co;2-9

  日期：1999.12

  A series of 2-amino-5-substituted pyridine derivatives was synthesized and their molluscicidal activity against white garden, Theba pisana (Muller), and brown garden, Helix aspersa (Muller), snails was investigated by two methods of application. Some of these compounds showed strong activity under laboratory conditions against the two types of snail. T pisana was more sensitive to the tested compounds than H aspersa. The most effective compounds were 2-amino-5-(benzotriazole-1-ylmethyl)-3-methylpyridine, 2-amino-5-[1-(benzotriazole-1-yl)nonyl]-3-methylpyridine and 2-[(1,2,4-triazole-1-ylmethyl) amino]-3-methylpyridine which exhibited high molluscicidal activity. The toxicity results are discussed in relation to the chemical structures. (C) 1999 Society of Chemical Industry.