Fmoc-Gly-Tyr(OH)-OBn | 652155-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Gly-Tyr(OH)-OBn
• 英文别名: benzyl (2S)-2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]-3-(4-hydroxyphenyl)propanoate
• CAS: 652155-94-7
• 化学式: C₃₃H₃₀N₂O₆
• 分子量: 550.611
• InChiKey: OOSAQZMNUXXZER-PMERELPUSA-N

物化性质

• 沸点：
  805.8±65.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  41.0
• 可旋转键数：
  10.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  113.96
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Fmoc-Gly-Tyr(OH)-OBn 在 三氧化硫 、 Biorad AG₅₀WX-8 resin sodium salt 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 反应 12.0h， 以90%的产率得到
  参考文献：
  名称：

  Syntheses of Heterobifunctional Candidate Ligands of P‐Selectin Containing Both Sulfated Lewis X Trisaccharide and Various Sulfated Peptides

  摘要：

  Various heterobifunctional glycopeptides containing both 3'-sulfated Lewis x and peptides containing at least one sulfated tyrosine were constructed onto a pentaerythritol backbone following a common strategy that relies on the condensation, through reductive amination, of aldehydes 9 or 17 with various peptides having a free terminal amino group. The corresponding homodimer of 3'-sulfated Lewis x linked to pentaerythritol was prepared for comparison of the inhibitory activities.

  DOI：

  10.1081/car-120026453
• 作为产物：
  描述：

  L-tyrosine benzyl ester 在 碳酸氢钠 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 36.0h， 生成 Fmoc-Gly-Tyr(OH)-OBn
  参考文献：
  名称：

  Syntheses of Heterobifunctional Candidate Ligands of P‐Selectin Containing Both Sulfated Lewis X Trisaccharide and Various Sulfated Peptides

  摘要：

  Various heterobifunctional glycopeptides containing both 3'-sulfated Lewis x and peptides containing at least one sulfated tyrosine were constructed onto a pentaerythritol backbone following a common strategy that relies on the condensation, through reductive amination, of aldehydes 9 or 17 with various peptides having a free terminal amino group. The corresponding homodimer of 3'-sulfated Lewis x linked to pentaerythritol was prepared for comparison of the inhibitory activities.

  DOI：

  10.1081/car-120026453

文献信息

• Syntheses of Heterobifunctional Candidate Ligands of P‐Selectin Containing Both Sulfated Lewis X Trisaccharide and Various Sulfated Peptides
  作者：Franck Dagron、André Lubineau

  DOI：10.1081/car-120026453

  日期：2003.12.31

  Various heterobifunctional glycopeptides containing both 3'-sulfated Lewis x and peptides containing at least one sulfated tyrosine were constructed onto a pentaerythritol backbone following a common strategy that relies on the condensation, through reductive amination, of aldehydes 9 or 17 with various peptides having a free terminal amino group. The corresponding homodimer of 3'-sulfated Lewis x linked to pentaerythritol was prepared for comparison of the inhibitory activities.