1-azido-2-chloro-4-(trifluoromethyl)benzene | 1115300-94-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-azido-2-chloro-4-(trifluoromethyl)benzene
• 英文别名: 1-Azido-2-chloro-4-trifluoromethyl-benzene
• CAS: 1115300-94-1
• 化学式: C₇H₃ClF₃N₃
• 分子量: 221.569
• InChiKey: YKENHQWWYDTADG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-azido-2-chloro-4-(trifluoromethyl)benzene 在 sodium methylate 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-(2-(ethylsulfonyl)-4-(trifluoromethyl)phenyl)-5-methyl-4-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazole
  参考文献：
  名称：

  TW2018/23211

  摘要：

  公开号：
• 作为产物：
  描述：

  3-氯-4-氨基三氟甲苯 在 sodium azide 、 溶剂黄146 、 sodium nitrite 作用下， 生成 1-azido-2-chloro-4-(trifluoromethyl)benzene
  参考文献：
  名称：

  DIARYLAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT

  摘要：

  本发明提供了由式(I)表示的化合物（在该式中，A1和A2分别独立地表示碳原子或氮原子；X1表示未取代或取代的C1-6烷基或类似物；n表示0至4的整数；R1表示未取代或取代的C1-6烷基硫基或类似物；B1和B4分别独立地表示碳原子、氮原子或类似物；R2和R3分别独立地表示氢原子、卤素基或类似物；Ar表示未取代或取代的C6-10芳基或类似物）或其盐，并且包括该化合物的有害生物控制剂。

  公开号：

  US20180160686A1

文献信息

• [EN] NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] DÉRIVÉS INÉDITS DE 1,2,3-TRIAZOLE UTILISABLES EN TANT QUE MODULATEURS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2009019278A1

  公开（公告）日：2009-02-12

  This invention relates to novel 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及新型的1,2,3-三唑衍生物，发现它们是尼古丁型乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩、内分泌疾病、神经退行性疾病、炎症、疼痛以及由滥用化学物质终止引起的戒断症状等疾病或障碍具有用处。
• [EN] NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] NOUVEAUX DÉRIVÉS DU DIPHÉNYL-1,2,3-TRIAZOLE UTILES EN TANT QUE MODULATEURS DE RÉCEPTEURS ACÉTYLCHOLINES NICOTINIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2010015583A1

  公开（公告）日：2010-02-11

  This invention relates to novel diphenyl 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的二苯基1,2,3-三唑衍生物，其被发现可以调节尼古丁乙酰胆碱受体。由于它们的药理特性，本发明中的化合物可能对于治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或疾病、内分泌疾病或疾病、神经退行性疾病或疾病、炎症、疼痛以及由于化学物质滥用终止而引起的戒断症状等多种疾病或疾病可能有用。
• One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists
  作者：Nagaraju Bashetti、J.V. Shanmukha Kumar、Naresh Varma Seelam、B. Prasanna、Akiva Mintz、Naresh Damuka、Sriram Devanathan、Kiran Kumar Solingapuram Sai

  DOI：10.1016/j.bmcl.2019.126707

  日期：2019.12

  We have synthesized a new series of 1,2,3-triazolo piperazine and piperidine carboxylate derivatives using a simple and one-pot click chemistry with significantly reduced reaction times (~5 min) and enhanced reaction yields (~95-98%). The fourteen novel compounds thus synthesized were tested for ability to target GPR119, a G-protein coupled target receptor that plays critical role in regulation of

  我们使用简单的一锅点击化学合成了一系列新的 1,2,3-三唑并哌嗪和哌啶羧酸盐衍生物，显着缩短了反应时间（约 5 分钟）并提高了反应产率（约 95-98%）。测试了由此合成的十四种新化合物靶向 GPR119 的能力，GPR119 是一种 G 蛋白偶联靶受体，在调节 2 型糖尿病中起关键作用。四种类似物（3e、3g、5e 和 5g）表现出与先前报道的 AR231453 对 GPR119 的活性相似或更好的 EC50 值。
• NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Nardi Antonio

  公开号：US20110201656A1

  公开（公告）日：2011-08-18

  This invention relates to novel diphenyl 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型二苯基1,2,3-三唑衍生物，发现它们是尼古丁乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或疾病、内分泌疾病或疾病、神经退行性疾病或疾病、炎症、疼痛和由于滥用化学物质的停止而引起的戒断症状等多种疾病或疾病具有用处。
• NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Nardi Antonio

  公开号：US20100222398A1

  公开（公告）日：2010-09-02

  This invention relates to novel 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新颖的1,2,3-三唑衍生物，这些衍生物被发现是乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或障碍、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症相关的疾病或障碍、疼痛和化学物质滥用终止引起的戒断症状等疾病或障碍有用。